ArticleJACC. Cardiovascular imaging2024
Prevalence of Aortic Valve Calcium and the Long-Term Risk of Incident Severe Aortic Stenosis.
Article in JACC. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Epidemiological and bioinformatics analyses of air pollution and genetic susceptibility in aortic stenosis risk.Nature communications · 2026Article
- Ten-year trajectory of Life's Essential 8 and aortic valve calcification.American journal of preventive cardiology · 2026Article
- Sex-Specific Prognostic Value of Aortic Valve Calcium and the Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis (MESA).Circulation. Cardiovascular imaging · 2026Article
- Lifetime Management of Aortic Stenosis: Evolving Strategies and Personalized Decision-Making.Journal of clinical medicine · 2026Review
- Race and Ethnic-Specific Burden of Aortic Valve Calcium and Its Association With Long-Term Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis.Circulation. Cardiovascular imaging · 2026Article
- Impact of age on aortic valve calcium progression and risk for aortic stenosis: multi-ethnic study of atherosclerosis.European heart journal. Cardiovascular Imaging · 2026Article
- Opportunistic automated aortic valve calcification assessment in low-cost, screening CT calcium score exams.Scientific reports · 2026Article
- Active endothelial and neural regulation of valve biology, health, and disease.Frontiers in cardiovascular medicine · 2026Review
- Long non-coding RNAs as molecular hubs integrating inflammatory and osteogenic pathways in calcific aortic valve disease.Frontiers in cardiovascular medicine · 2026Review
- The association between time-weighted cumulative life's essential 8 and aortic valve calcification.Frontiers in cardiovascular medicine · 2026Article
- Review
- The velocity ratio as a predictor of valve calcium degeneration in aortic stenosis with low flow status.Cardiovascular ultrasound · 2025Article
- Coronary Artery Calcium Scoring on Dedicated Cardiac CT and Noncardiac CT Scans.Radiology. Cardiothoracic imaging · 2025Review
- Long-Term Outcomes in Aortic Stenosis: Mortality Analysis in a Selected Patient Group.Journal of personalized medicine · 2025Article
- Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population.Cardiovascular diabetology · 2025Article
- Inflammatory markers and calcification of coronary arteries, aorta and cardiac valves: Findings from the atherosclerosis risk in communities study.American journal of preventive cardiology · 2025Article
- Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis.European heart journal · 2025Article
- Aortic Valve Calcium: A Narrative Review of its Role in the Assessment of Aortic Stenosis and as a Predictor of Post-transcatheter Aortic Valve Implantation Outcomes.Interventional cardiology (London, England) · 2025Review
- Dichotomous roles of IL-36 and IL-38 in cardiovascular disease.Frontiers in immunology · 2025Review
- Global, Regional, and National Burden of Valvular Heart Disease, 1990 to 2021.Journal of the American Heart Association · 2024Article
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Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundAortic valve calcification (AVC) is a principal mechanism underlying aortic stenosis (AS).
objectivesThis study sought to determine the prevalence of AVC and its association with the long-term risk for severe AS.
methodsNoncontrast cardiac computed tomography was performed among 6,814 participants free of known cardiovascular disease at MESA (Multi-Ethnic Study of Atherosclerosis) visit 1. AVC was quantified using the Agatston method, and normative age-, sex-, and race/ethnicity-specific AVC percentiles were derived. The adjudication of severe AS was performed via chart review of all hospital visits and supplemented with visit 6 echocardiographic data. The association between AVC and long-term incident severe AS was evaluated using multivariable Cox HRs.
resultsAVC was present in 913 participants (13.4%). The probability of AVC >0 and AVC scores increased with age and were generally highest among men and White participants. In general, the probability of AVC >0 among women was equivalent to men of the same race/ethnicity who were approximately 10 years younger. Incident adjudicated severe AS occurred in 84 participants over a median follow-up of 16.7 years. Higher AVC scores were exponentially associated with the absolute risk and relative risk of severe AS with adjusted HRs of 12.9 (95% CI: 5.6-29.7), 76.4 (95% CI: 34.3-170.2), and 380.9 (95% CI: 169.7-855.0) for AVC groups 1 to 99, 100 to 299, and ≥300 compared with AVC = 0.
conclusionsThe probability of AVC >0 varied significantly by age, sex, and race/ethnicity. The risk of severe AS was exponentially higher with higher AVC scores, whereas AVC = 0 was associated with an extremely low long-term risk of severe AS. The measurement of AVC provides clinically relevant information to assess an individual's long-term risk for severe AS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.