Evidence map›Paper›PMID 37177999›Full record

ArticleNucleic acids research2023

miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations.

Ernesto Aparicio-Puerta, Pascal Hirsch, Georges P Schmartz, Fabian Kern, Tobias Fehlmann, Andreas Keller

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
22.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ernesto Aparicio-PuertaClinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-3470-1425
Pascal HirschClinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.
Georges P SchmartzClinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-9627-9223
Fabian KernClinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-8223-3750
Tobias FehlmannClinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-1967-2918
Andreas KellerClinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-5361-0895
Saarland University · DEHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in regulating diverse biological processes. Extracting functional insights from a list of miRNAs is challenging, as each miRNA can potentially interact with hundreds of genes. To address this challenge, we developed miEAA, a flexible and comprehensive miRNA enrichment analysis tool based on direct and indirect miRNA annotation. The latest release of miEAA includes a data warehouse of 19 miRNA repositories, covering 10 different organisms and 139 399 functional categories. We have added information on the cellular context of miRNAs, isomiRs, and high-confidence miRNAs to improve the accuracy of the results. We have also improved the representation of aggregated results, including interactive Upset plots to aid users in understanding the interaction among enriched terms or categories. Finally, we demonstrate the functionality of miEAA in the context of ageing and highlight the importance of carefully considering the miRNA input list. MiEAA is free to use and publicly available at https://www.ccb.uni-saarland.de/mieaa/.

Indexed as

MicroRNAsSoftwareDatabases, Nucleic AcidMicroRNAs

Identifiers

PMID37177999
PMCPMC10320052
OpenAlexW4376503781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.