Evidence map›Paper›PMID 37177534›Full record

ArticleSensors (Basel, Switzerland)2023

Improved Resting-State Functional MRI Using Multi-Echo Echo-Planar Imaging on a Compact 3T MRI Scanner with High-Performance Gradients.

Daehun Kang, Myung-Ho In, Hang Joon Jo, Maria A Halverson, Nolan K Meyer, Zaki Ahmed, Erin M Gray, Radhika Madhavan, Thomas K Foo, Brice Fernandez and 6 more

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daehun KangDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3792-3303
Myung-Ho InDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-8001-6237
Hang Joon JoDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Maria A HalversonDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Nolan K MeyerDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Zaki AhmedDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-5648-0590
Erin M GrayDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Radhika MadhavanGE Global Research, Niskayuna, NY 12309, USA.
Thomas K FooGE Global Research, Niskayuna, NY 12309, USA.
Brice FernandezGE Healthcare, 78530 Buc, France.ORCID 0000-0002-8693-2313
David F BlackDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Kirk M WelkerDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Joshua D TrzaskoDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
John HustonDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-0584-9460
Matt A BernsteinDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Yunhong ShuDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-7521-9088

Funding

Lightweight, Compact, Low-Cryogen, Head-Only 7T MRI for High Spatial Resolution Brain ImagingU01EB026976 · NIBIB · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI FOO, THOMAS K, SHU, YUNHONG · 2018 to 2022
$13.9M
High-performance compact 3T MRI: Technical optimization for advanced brain imagingU01EB024450 · NIBIB · MAYO CLINIC ROCHESTER · PI BERNSTEIN, MATTHEW A., FOO, THOMAS K · 2017 to 2021
$5.3M
NIBIB NIH HHS U01 EB024450NIBIB NIH HHS U01EB024450NIBIB NIH HHS U01 EB026976NIBIB NIH HHS U01EB026976
6 · The paper itself

Abstract

In blood-oxygen-level-dependent (BOLD)-based resting-state functional (RS-fMRI) studies, usage of multi-echo echo-planar-imaging (ME-EPI) is limited due to unacceptable late echo times when high spatial resolution is used. Equipped with high-performance gradients, the compact 3T MRI system (C3T) enables a three-echo whole-brain ME-EPI protocol with smaller than 2.5 mm isotropic voxel and shorter than 1 s repetition time, as required in landmark fMRI studies. The performance of the ME-EPI was comprehensively evaluated with signal variance reduction and region-of-interest-, seed- and independent-component-analysis-based functional connectivity analyses and compared with a counterpart of single-echo EPI with the shortest TR possible. Through the multi-echo combination, the thermal noise level is reduced. Functional connectivity, as well as signal intensity, are recovered in the medial orbital sulcus and anterior transverse collateral sulcus in ME-EPI. It is demonstrated that ME-EPI provides superior sensitivity and accuracy for detecting functional connectivity and/or brain networks in comparison with single-echo EPI. In conclusion, the high-performance gradient enabled high-spatial-temporal resolution ME-EPI would be the method of choice for RS-fMRI study on the C3T.

Indexed as

Brain MappingEcho-Planar ImagingBrainImage Processing, Computer-AssistedMagnetic Resonance ImagingBOLDcompact 3TfMRIgradient systemmulti-echo EPIresting stateslew rate

Identifiers

PMID37177534
PMCPMC10181561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.