Evidence map›Paper›PMID 37176772›Full record

ArticleJournal of clinical medicine2023

The Presence of Myosteatosis Is Associated with Age, Severity of Liver Disease and Poor Outcome and May Represent a Prodromal Phase of Sarcopenia in Patients with Liver Cirrhosis.

Eleni Geladari, Theodoros Alexopoulos, Meropi D Kontogianni, Larisa Vasilieva, Iliana Mani, Roxane Tenta, Vasilios Sevastianos, Ioannis Vlachogiannakos, Alexandra Alexopoulou

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Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eleni Geladari3rd Department of Internal Medicine & Liver Outpatient Clinic, Evangelismos General Hospital, 106 76 Athens, Greece.
Theodoros AlexopoulosGastroenterology Department, Medical School, National & Kapodistrian University of Athens, Laiko General Hospital, 115 27 Athens, Greece.
Meropi D KontogianniDepartment of Nutrition & Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 176 76 Kallithea, Greece.ORCID 0000-0003-3168-8867
Larisa VasilievaAlexandra General Hospital, Gastroenterology, 115 28 Athens, Greece.
Iliana Mani2nd Department of Internal Medicine & Research Laboratory, Medical School, National & Kapodistrian University of Athens, Hippokration General Hospital, 115 28 Athens, Greece.
Roxane TentaDepartment of Nutrition & Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 176 76 Kallithea, Greece.ORCID 0000-0002-4867-6945
Vasilios Sevastianos3rd Department of Internal Medicine & Liver Outpatient Clinic, Evangelismos General Hospital, 106 76 Athens, Greece.
Ioannis VlachogiannakosGastroenterology Department, Medical School, National & Kapodistrian University of Athens, Laiko General Hospital, 115 27 Athens, Greece.
Alexandra Alexopoulou2nd Department of Internal Medicine & Research Laboratory, Medical School, National & Kapodistrian University of Athens, Hippokration General Hospital, 115 28 Athens, Greece.ORCID 0000-0003-1991-7436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsMyosteatosis implies impaired muscle quality. The aim of the study was to investigate the association of myosteatosis with other muscle abnormalities and its role in the prognosis of liver cirrhosis (LC).

methodSkeletal muscle index (SMI) and myosteatosis were measured by computed tomography. Myosteatosis was defined as muscle radiodensity and evaluated according to dry body mass index (BMI). Median values and interquartile range were used for continuous and count (percentage) for categorical variables.

resultsA total of 197 consecutive patients were included (age 61 (IQR 52-68); 67% male; MELD score 11 (interquartile range 7.5-16)). Myosteatosis was identified in 73.6% and sarcopenia in 44.6% of patients. Myosteatosis was positively associated with age (

conclusionsThe presence of myosteatosis was associated with advanced age, low skeletal mass and more severe LC. Myosteatosis was associated with poor prognosis and may represent a prodromal phase of muscle degeneration before the development of sarcopenia.

Indexed as

liver cirrhosismyosteatosissarcopeniaskeletal muscle wastingsurvival

Identifiers

PMID37176772
PMCPMC10179726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.