Evidence map›Paper›PMID 37176730›Full record

ArticleJournal of clinical medicine2023

Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Is a Biomarker Associated with Left Ventricular Hypertrophy in the Elderly, Specifically in Women.

Rafał Nikodem Wlazeł, Agnieszka Guligowska, Zuzanna Chrząstek, Tomasz Kostka, Anna Jegier, Iwona Szadkowska

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rafał Nikodem WlazełDepartment of Laboratory Diagnostics and Clinical Biochemistry, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland.ORCID 0000-0003-3316-4063
Agnieszka GuligowskaDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Plac Hallera 1, 90-647 Lodz, Poland.ORCID 0000-0002-6928-3892
Zuzanna ChrząstekDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Plac Hallera 1, 90-647 Lodz, Poland.ORCID 0000-0001-9562-178X
Tomasz KostkaDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, Plac Hallera 1, 90-647 Lodz, Poland.ORCID 0000-0003-0437-650X
Anna JegierDepartment of Sports Medicine, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland.
Iwona SzadkowskaDepartment of Sports Medicine, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland.ORCID 0000-0003-3804-145X
Medical University of Lodz · PL

Funding

Medical University of Lodz 503/6-077-01/503-61-001-19-00, 503/3-015-03/503-51-001-19-00 and 503/6-029-05/503-61-001-19-00.
6 · The paper itself

Abstract

Left ventricular hypertrophy (LVH) may result in the development of heart failure, which is widespread among people of advanced age. The pathophysiology of LVH is complex and its biochemical pathways are not fully understood in this group. Elevated soluble urokinase-type plasminogen activator receptor (suPAR), a biomarker of immune activation, including fibrosis, reflects subclinical organ damage in systematic diseases. The present study assesses the clinical role of suPAR measurement in determination of LVH-associated cardiac disorders in the elderly. The studied population consisted of 238 individuals aged 76-91 years; of these, 139 (58%) were diagnosed with LVH. Serum biomarkers measurement (suPAR, troponin T, NT-proBNP and CRP) and echocardiography were performed in all subjects. The suPAR level was significantly higher in the LVH group (4.01 vs. 3.82 ng/mL,

Indexed as

agingbiomarkercardiac remodelingechocardiogramleft ventricular hypertrophysoluble urokinase-type plasminogen activator receptorsuPAR

Identifiers

PMID37176730
PMCPMC10178939
OpenAlexW4372286270

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.