Evidence map›Paper›PMID 37176684›Full record

ReviewJournal of clinical medicine2023

Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions.

David Martin, Piero Alberti, Nicolas Demartines, Melanie Phillips, John Casey, Andrew Sutherland

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

David MartinDepartment of Visceral Surgery and Transplantation, University Hospital CHUV, University of Lausanne (UNIL), 1015 Lausanne, Switzerland.ORCID 0000-0003-1585-5231
Piero AlbertiEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
Nicolas DemartinesDepartment of Visceral Surgery and Transplantation, University Hospital CHUV, University of Lausanne (UNIL), 1015 Lausanne, Switzerland.ORCID 0000-0002-1530-3114
Melanie PhillipsEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
John CaseyEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
Andrew SutherlandEdinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
Edinburgh Royal Infirmary · GBUniversity of Lausanne · CH

Funding

Medical Research Council MR/V038087/1
6 · The paper itself

Abstract

Whole-organ pancreas and islets transplantations are two therapeutic options to treat type 1 diabetic patients resistant to optimised medical treatment in whom severe complications develop. Selection of the best option for β-cell replacement depends on several factors such as kidney function, patient comorbidities, and treatment goals. For a patient with end-stage kidney disease, the treatment of choice is often a simultaneous transplant of the pancreas and kidney (SPK). However, it remains a major surgical procedure in patients with multiple comorbidities and therefore it is important to select those who will benefit from it. Additionally, in view of the organ shortage, new strategies to improve outcomes and reduce immune reactions have been developed, including dynamic organ perfusion technologies, pancreas bioengineering, and stem cell therapies. The purpose of this article is to review the indications, surgical techniques, outcomes, and future directions of whole-organ pancreas and islets transplantations.

Indexed as

islets transplantationpancreas transplantationtype 1 diabetes mellitus

Identifiers

PMID37176684
PMCPMC10179530
OpenAlexW4367596575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.