ArticleJournal of clinical medicine2023
Towards Genetic Dissection of Skeletal Class III Malocclusion: A Review of Genetic Variations Underlying the Phenotype in Humans and Future Directions.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Applying Automated Artificial Intelligence Models on Lateral Cephalometric Parameters to Accurately Classify Arab Orthodontic Patient Patterns.Clinical and experimental dental research · 2026Article
- Sex-Dependent Prevalence of Sagittal Skeletal, Dental Malocclusions in Romanian Orthodontic Patients: An Observational Study.Journal of clinical medicine · 2026Article
- Early Protraction Facemask Followed by Fixed Appliance Therapy in a Growing Patient With Skeletal Class III Malocclusion: A Case Report.Case reports in dentistry · 2026Article
- Three-Dimensional Evaluation of Temporomandibular Joint Intraosseous Distances According to Skeletal Class Using Cone Beam Computed Tomography.Clinical, cosmetic and investigational dentistry · 2026Article
- Mandibular Prognathism in Dolang Sheep: Hi-C Evidence for Localized TAD Remodeling at Craniofacial Loci.Animals : an open access journal from MDPI · 2025Article
- Diagnostic Support in Dentistry Through Artificial Intelligence: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- FGF9-FGFR2 Signaling via Osteocytes-Preosteoblasts Crosstalks to Mediate Mechanotransduction-Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Involvement of the gene encoding the collagen type II alpha 1 chain in mandibular mobility.BMC oral health · 2025Article
- The Therapeutic Approaches Dealing with Malocclusion Type III-Narrative Review.Life (Basel, Switzerland) · 2025Review
- The relationship between vertical malocclusions and ossification changes in the cranial base and upper cervical spine.Scientific reports · 2025Article
- Hierarchical clustering analysis & machine learning models for diagnosing skeletal classes I and II in German patients.BMC oral health · 2025Article
- Morphogenetic Expression of Genes in Class II Division 2 Malocclusion: A Pedigree Study.Cureus · 2025Article
- Expert consensus on early orthodontic treatment of class III malocclusion.International journal of oral science · 2025Review
- System genetic analysis of intestinal cancer and periodontitis development as influenced by aging and diabesity using Collaborative Cross mice.Animal models and experimental medicine · 2025Review
- Genetic factors underlying Mandibular prognathism: insights from recent human and animal studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Immunohistochemical Evaluation of Bone Remodeling Following Compressive Force on Mandibular Condyle.Biology · 2025Article
- Clustering and Machine Learning Models of Skeletal Class I and II Parameters of Arab Orthodontic Patients.Journal of clinical medicine · 2025Article
- Cross-Sectional Observational Study of the Differences in Cephalometric Parameters in German Class I/II Orthodontic Patients.International journal of dentistry · 2025Article
- Lateral cephalometric parameters among Arab skeletal classes II and III patients and applying machine learning models.Clinical oral investigations · 2024Observational
- Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSkeletal abnormalities and malocclusions have varied features that impact populations globally, impairing aesthetics and lowering life quality. The prevalence of the Skeletal Class III disease is the lowest among all angle malocclusions, with varied prevalence across nations. Environmental, genetic, and societal factors play a role in its numerous etiologies. In this study, we conducted a thorough search across the published data relating to quantitative trait loci (QTL) and the genes associated with Class III progression in humans, discussed these findings and their limitations, and proposed future directions and strategies for studying this phenotype.
methodsAn inclusive search of published papers in the PubMed and Google Scholar search engines using the following terms: 1. Human skeletal Class III; 2. Genetics of Human skeletal Class III; 3. QTL mapping and gene associated with human skeletal Class III; 4. enriched skeletal Class-III-malocclusion-associated pathways.
resultsOur search has found 53 genes linked with skeletal Class III malocclusion reported in humans, genes associated with epigenetics and phenomena, and the top 20 enriched pathways associated with skeletal Class III malocclusion.
conclusionsThe human investigations yielded some contentious conclusions. We conducted a genome-wide association study (GWAS), an epigenetics-wide association study (EWAS), RNA-seq analysis, integrating GWAS and expression quantitative trait loci (eQTL), micro- and small-RNA, and long non-coding RNA analysis in tissues connected to skeletal Class III malocclusion phenotype in tissues connected with the skeletal phenotype. Finally, we invite regional, national, and international orthodontists and surgeons to join this effort by contributing human samples with skeletal Class III malocclusion following the accepted Helsinki ethical protocol to challenge these phenomena jointly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.