ArticleJournal of clinical medicine2023
Serum Pancreatic Stone Protein Reference Values in Healthy Pregnant Women: A Prospective Cohort Study.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Serum Pancreatic Stone Protein Across the Spectrum of Hypertensive Disorders of Pregnancy: Discrimination of Preeclampsia Compared with Conventional Inflammatory Indices.Medicina (Kaunas, Lithuania) · 2026Article
- Diagnostic Value of Serum Pancreatic Stone Protein in Gestational Diabetes Mellitus: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Toward Artificial Intelligence in Oncology and Cardiology: A Narrative Review of Systems, Challenges, and Opportunities.Journal of clinical medicine · 2025Article
- Diagnostic and Prognostic Utilities of Pancreatic Stone Protein in Patients with Suspected Sepsis.Diagnostics (Basel, Switzerland) · 2024Article
- The Role of Pancreatic Stone Protein (PSP) as a Biomarker of Pregnancy-Related Diseases.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn non-pregnant populations, pancreatic stone protein (PSP) has been reported to have a higher diagnostic performance for identifying severe inflammatory and infectious disease than other established biomarkers.
objectiveTo generate reference values for serum PSP in pregnancy and compare them to the values of the general healthy population.
designA prospective cohort study.
settingA single center. POPULATION: Healthy women with singleton and multiple pregnancies.
methodsThis is a prospective single-center cohort study. Between 2013 and 2021, samples of 5 mL peripheral blood were drawn from 440 healthy pregnant women. Therein, 393 cases were singletons and 47 were multiple pregnancies. Serum PSP levels were measured by specific enzyme-linked immunosorbent assay. The main outcome measures were serum PSP level (ng/mL) reference values in healthy pregnant women.
resultsThe mean PSP reference values in women with singleton pregnancies were 7.9 ± 2.6 ng/mL (95% CI; 2.69-13.03 ng/mL). The PSP values in women with multiple pregnancies (9.17 ± 3.06 ng/mL (95% CI; 3.05-15.28 ng/mL)) were significantly higher (
conclusionThe PSP values in healthy pregnant women (4-12 ng/mL) were in the range of the reference values of the general healthy population (8-16 ng/mL). This insight blazes a trail for further clinical studies on the use of PSP as a potential novel biomarker for the early detection of pregnancy-related diseases such as chorioamnionitis.
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