ReviewJournal of clinical medicine2023
2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 158 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"The Impact of Beta-Lactam Infusion Strategy on Treatment Efficacy in Sepsis and Septic Shock : Extended vs. Intermittent Dosing in the ICU"
Evaluation of the Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Who cites it
158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- Diagnostic value of [European journal of nuclear medicine and molecular imaging · 2026Pooled it
- Sepsis screening tools in resource-limited settings: a systematic review and meta-analysis of diagnostic accuracy in low- and middle-income countries.Frontiers in public health · 2026Pooled it
- Rate of bacterial positivity following antibiotic initiation: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Illustrating the functional heterogeneity of M-MDSCs to predict sepsis outcomes.Journal of advanced research · 2026Article
- Two-dimensional shear wave elastography-based assessment of liver stiffness in critically ill patients with septic shock: a prospective observational study.Internal and emergency medicine · 2026Article
- Beyond Fluid Responsiveness: Why Venous Congestion Matters in Sepsis.Current medical science · 2026Article
- Sex-Related Differences in Clinical Characteristics and Outcomes Among Patients Clinically Managed for Suspected Bacterial Infection in the Emergency Department.Medicina (Kaunas, Lithuania) · 2026Observational
- HIMAP POCUS protocol for early evaluation of undifferentiated shocked patients at the emergency department: A prospective study of diagnostic accuracy and time efficiency.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- Circulating calprotectin (C-CLP) as a potential biomarker for early diagnosis of intra-abdominal infections.Updates in surgery · 2026Article
- Non-Linear Threshold Effect of Dynamic Estimated Plasma Volume Status on Revealing In-Hospital Mortality Risk in Sepsis.The Kaohsiung journal of medical sciences · 2026Article
- Comorbidities and Inflammation: How Chronic Diseases Prime the Host Response in Sepsis.International journal of molecular sciences · 2026Review
- Bacteremia evaluation with T2 magnetic resonance in the emergency room (BETTER).Microbiology spectrum · 2026Observational
- Admission Plasma Lipopolysaccharide-binding protein, Procalcitonin, and Lactate for Early Identification of Nosocomial Infection in Cirrhotic Patients With Upper Gastrointestinal Bleeding: A Retrospective Analysis.The Kaohsiung journal of medical sciences · 2026Article
- Altered Mental Status in Emergency Department Patient with Cerebral Septic Emboli from Infective Endocarditis: Case Report.Clinical practice and cases in emergency medicine · 2026Article
- Significant Publications on Infectious Diseases Pharmacotherapy in 2024.Journal of pharmacy practice · 2026Review
- CutaneousInternational journal of molecular sciences · 2026Review
- Septic cardiomyopathy: Fact or fiction?American heart journal plus : cardiology research and practice · 2026Review
- FIRST-ICU: forecasting interventions and risk stratification in the ICU using graph neural network autoencoders.NPJ digital medicine · 2026Article
- Diagnostic accuracy of PCT, IL-6, and MR-ProADM for early identification of sepsis in the emergency department.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Observational
- Clinical Management and Outcomes of Urosepsis in Relation to Diagnostic Complexity and Microbiological Profile.Medicina (Kaunas, Lithuania) · 2026Observational
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis/septic shock is a life-threatening and time-dependent condition that requires timely management to reduce mortality. This review aims to update physicians with regard to the main pillars of treatment for this insidious condition.
methodsPubMed, Scopus, and EMBASE were searched from inception with special attention paid to November 2021-January 2023.
resultsThe management of sepsis/septic shock is challenging and involves different pathophysiological aspects, encompassing empirical antimicrobial treatment (which is promptly administered after microbial tests), fluid (crystalloids) replacement (to be established according to fluid tolerance and fluid responsiveness), and vasoactive agents (e.g., norepinephrine (NE)), which are employed to maintain mean arterial pressure above 65 mmHg and reduce the risk of fluid overload. In cases of refractory shock, vasopressin (rather than epinephrine) should be combined with NE to reach an acceptable level of pressure control. If mechanical ventilation is indicated, the tidal volume should be reduced from 10 to 6 mL/kg. Heparin is administered to prevent venous thromboembolism, and glycemic control is recommended. The efficacy of other treatments (e.g., proton-pump inhibitors, sodium bicarbonate, etc.) is largely debated, and such treatments might be used on a case-to-case basis.
conclusionsThe management of sepsis/septic shock has significantly progressed in the last few years. Improving knowledge of the main therapeutic cornerstones of this challenging condition is crucial to achieve better patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.