Evidence map›Paper›PMID 37176589›Full record

ArticleJournal of clinical medicine2023

Psychiatric Symptoms and Cognitive Disorders in Behçet's Disease: A Single-Center, Cross-Sectional Study.

Fanny Urbain, Isabelle Hardy-Léger, Ghaidaa Adebs-Nasser, Mathilde de Menthon, Cécile Pivert, Aude Mausoléo, Ariane Laparra, Nathalie Lerolle, Paul-Albert Domnariu, Olivier Lambotte and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Fanny UrbainInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Isabelle Hardy-LégerInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Ghaidaa Adebs-NasserNeuro-Imaging Department, AP-HP, Groupe Hospitalier Universitaire Paris Saclay Hôpital Bicêtre, F-94275 Le Kremlin-Bicêtre, France.
Mathilde de MenthonInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Cécile PivertInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.ORCID 0009-0003-1373-8768
Aude MausoléoInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Ariane LaparraInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Nathalie LerolleInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Paul-Albert DomnariuInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Olivier LambotteInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Christian DenierFaculty of Medicine, Paris Saclay University, F-94275 Le Kremlin-Bicêtre, France.
Cécile GoujardInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Alicia Castro-GordonInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.
Nicolas NoelInternal Medecine and Clinical Immunology Department, AP-HP, Hôpital Bicêtre, Groupe Hospitalier Universitaire Paris Saclay, F-94275 Le Kremlin-Bicêtre, France.ORCID 0000-0003-4055-617X
Assistance Publique – Hôpitaux de Paris · FRInserm · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBehçet's disease (BD) is a rare form of vasculitis involving both veins and arteries of all calibers. Psychological symptoms and cognitive impairment appear to be frequent, but few data are available.

methodsAll consecutive patients in our center fulfilling the 2013 BD criteria underwent a psychometric evaluation with auto- (SCL-90-R and Modified Fatigue Index) and hetero-questionnaires (MINI). A standardized test battery assessed cognitive dysfunction. Data were correlated with BD activity as well as quality of life (SF-36).

resultsWe included 20 consecutive patients (16 men, four women) with a median [IQR] age of 38 (30.0-45.5) and a median disease duration of 7 years (1.8-11.0). Five patients had an abnormal brain MRI. The SCL-90-R questionnaire highlighted eight psychopathological profiles (42.1%) that correlated with altered quality of life and more severe fatigue. The most frequent symptoms were anxiety (9/19, 47.4%), somatization (8/19, 42.1%) and phobia (5/19, 26.3%). Psychopathological symptoms appeared to be more severe, but not more frequent, in neuro-Behçet's patients. Based on standardized cognitive evaluation, nine patients had cognitive impairment defined by three or more altered tests. Notably, 6/9 patients did not have any complaint of memory loss and were thus considered ansognostic.

conclusionCognitive involvement was significantly associated with BD activity score (BSAS) but not with brain MRI abnormalities.

Indexed as

Behçet’s diseasecognitive impairmentneuropsychiatrypsychopathology

Identifiers

PMID37176589
PMCPMC10179639
OpenAlexW4367181518

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.