Evidence map›Paper›PMID 37176563›Full record

ReviewJournal of clinical medicine2023

Hypertensive Heart Disease-The Imaging Perspective.

Tevfik F Ismail, Simon Frey, Beat A Kaufmann, David J Winkel, Daniel T Boll, Michael J Zellweger, Philip Haaf

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07544888 (Comparison of Effectiveness of Combination of Valsartan and Hydrochlorothiazide Versus Valsartan Alone in the Treatment of Hypertensive Heart Disease), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07544888 phase1completednot on this mapstarted 2025, after this paper: background citation

Comparison of Effectiveness of Combination of Valsartan and Hydrochlorothiazide Versus Valsartan Alone in the Treatment of Hypertensive Heart Disease

TypeinterventionalSponsorShaikh Zayed Hospital, LahoreRan2025 to 2026Enrolled118ConditionsHeart Diseases, HypertensionArmsValsartan + Hydrochlorothiazide
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Identification of potential biomarkers for hypertension based on transcriptomic analysis in rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tevfik F IsmailKing's College London & Cardiology Department, School of Biomedical Engineering and Imaging Sciences, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.ORCID 0000-0002-1691-7599
Simon FreyDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.ORCID 0000-0002-6786-7931
Beat A KaufmannDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
David J WinkelDepartment of Radiology, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland.ORCID 0000-0001-7051-8022
Daniel T BollDepartment of Radiology, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland.
Michael J ZellwegerDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Philip HaafDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.ORCID 0000-0002-5657-6637

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertensive heart disease (HHD) develops in response to the chronic exposure of the left ventricle and left atrium to elevated systemic blood pressure. Left ventricular structural changes include hypertrophy and interstitial fibrosis that in turn lead to functional changes including diastolic dysfunction and impaired left atrial and LV mechanical function. Ultimately, these changes can lead to heart failure with a preserved (HFpEF) or reduced (HFrEF) ejection fraction. This review will outline the clinical evaluation of a patient with hypertension and/or suspected HHD, with a particular emphasis on the role and recent advances of multimodality imaging in both diagnosis and differential diagnosis.

Indexed as

cardiac amyloidosiscardiovascular magnetic resonancecomputed tomographyechocardiographyFabry’s diseasehypertensive heart diseasehypertrophic cardiomyopathymyocardial perfusion scintigraphyPET

Identifiers

PMID37176563
PMCPMC10179093

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.