Evidence map›Paper›PMID 37176535›Full record

ArticleJournal of clinical medicine2023

Risk-Benefit of IBD Drugs: A Physicians and Patients Survey.

Ferdinando D'Amico, Sophie Vieujean, Benedicte Caron, Laurent Peyrin-Biroulet, Silvio Danese

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Ferdinando D'AmicoDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Sophie VieujeanHepato-Gastroenterology and Digestive Oncology, University Hospital CHU of Liège, 4000 Liège, Belgium.ORCID 0000-0002-1859-7146
Benedicte CaronINSERM, NGERE, University of Lorraine, F-54000 Nancy, France.
Laurent Peyrin-BirouletINSERM, NGERE, University of Lorraine, F-54000 Nancy, France.
Silvio DaneseDepartment of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0001-7341-1351
Inserm · FRCentre Hospitalier Universitaire de Liège · BEHumanitas University · ITVita-Salute San Raffaele University · IT

Funding

Pfizer (Italy) na
6 · The paper itself

Abstract

backgroundTreatment choices for patients with inflammatory bowel disease (IBD) are based on the balance between risks and benefits. Our AI was to compare the perspectives of patients and physicians in evaluating the risks and benefits before initiating therapy for IBD.

methodsAn anonymous survey was conducted between March and August 2022. All patients with confirmed IBD and all physicians who attended an IBDscope webinar were invited to participate.

resultsIn total, 367 patients and 146 physicians participated. For most patients (71.4%) and physicians (89.0%), efficacy and safety were equally important. Clinical improvement and clinical remission were the most relevant outcomes for patients (90.9 and 88.4), while clinical remission and endoscopic remission were for physicians (90.0 and 87.6). The main factors in the benefit-risk assessment were quality of life (95.1%), disease activity (87.5%), and presence of comorbidities (84.5%) for patients, and presence of comorbidities (99.3%), disease activity (97.9%), and prior failure to biologics/small molecules (96.6%) for physicians. Based on patients' and physicians' opinions, the risk of serious infections, malignancies, cardiovascular events, death, relapse, all infections, surgery, and hospitalization should be included in the benefit-risk assessment.

conclusionPhysicians and patients have different priorities in evaluating the benefit-risk balance of a new therapy.

Indexed as

benefit-riskinflammatory bowel diseasepatientsphysicians

Identifiers

PMID37176535
PMCPMC10179123
OpenAlexW4366832876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.