Evidence map›Paper›PMID 37176532›Full record

ArticleJournal of clinical medicine2023

Intrahepatic Cholangiocarcinoma and Acute Intermittent Porphyria: A Case Report.

Claudio Carmine Guida, Maria Nardella, Leonardo Fiorentino, Tiziana Latiano, Francesco Napolitano, Gaetano Ferrara, Annalisa Crisetti, Gianluigi Mazzoccoli, Francesco Aucella, Filippo Aucella

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Liver transplantation and primary liver cancer in porphyria.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Claudio Carmine GuidaInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Maria NardellaInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Leonardo FiorentinoAnatomical Pathology Unit, "Perrino" Hospital, 72100 Brindisi, Italy.
Tiziana LatianoDivision of Oncology, Fondazione IRCCS "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.
Francesco NapolitanoInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Gaetano FerraraInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Annalisa CrisettiInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Gianluigi MazzoccoliDivision of Internal Medicine and Chronobiology Laboratory, Department of Medical Sciences, Fondazione IRCCS "Casa Sollievo della Sofferenza", 71013 San Giovanni Rotondo, Italy.ORCID 0000-0003-3535-7635
Francesco AucellaInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Filippo AucellaInterregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0003-1027-7049
Casa Sollievo della Sofferenza · ITOspedale A. Perrino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients suffering from different forms of acute hepatic porphyria present a high risk of primary liver cancer, specifically hepatocellular carcinoma and cholangiocarcinoma, determined by the activity of the disease even though an exact mechanism of carcinogenesis has not been recognized yet. Here, we present the clinical case of a 72-year-old woman who, approximately 29 years after the diagnosis of acute intermittent porphyria, presented with intrahepatic cholangiocarcinoma with a histological diagnosis of adenocarcinoma starting from the biliary-pancreatic ducts, which was diagnosed during the clinical and anatomopathological evaluation of a pathological fracture of the femur.

Indexed as

acute hepatic porphyriacholangiocarcinomadelta aminolevulinic acidhydroxymethylbilane synthaseporphobilinogen

Identifiers

PMID37176532
PMCPMC10178950
OpenAlexW4366825801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.