Evidence map›Paper›PMID 37176490›Full record

ReviewJournal of clinical medicine2023

The Impact of Atrial Fibrillation Treatment Strategies on Cognitive Function.

Neil Bodagh, Irum Kotadia, Ali Gharaviri, Fernando Zelaya, Jonathan Birns, Ajay Bhalla, Peter Sommerville, Steven Niederer, Mark O'Neill, Steven E Williams

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Beyond the beats: a systematic review of the underlying inflammatory pathways between atrial fibrillation and cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. The Impact of Cognitive Impairment on Cardiovascular Disease.Journal of the American College of Cardiology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Neil BodaghSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID 0000-0001-5475-5298
Irum KotadiaSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Ali GharaviriCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Fernando ZelayaSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Jonathan BirnsSt Thomas' Hospital, Guys and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Ajay BhallaSt Thomas' Hospital, Guys and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Peter SommervilleSt Thomas' Hospital, Guys and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Steven NiedererSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Mark O'NeillSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Steven E WilliamsSchool of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID 0000-0002-7266-2084
King's College London · GBSt Thomas' Hospital · GBUniversity of Edinburgh · GB

Funding

British Heart Foundation FS/20/26/34952British Heart Foundation FS/CRTF/21/24166British Heart Foundation PG/19/44/34368British Heart Foundation RE/18/5/34216British Heart Foundation RG/20/4/34803
6 · The paper itself

Abstract

There is increasing evidence to suggest that atrial fibrillation is associated with a heightened risk of dementia. The mechanism of interaction is unclear. Atrial fibrillation-induced cerebral infarcts, hypoperfusion, systemic inflammation, and anticoagulant therapy-induced cerebral microbleeds, have been proposed to explain the link between these conditions. An understanding of the pathogenesis of atrial fibrillation-associated cognitive decline may enable the development of treatment strategies targeted towards the prevention of dementia in atrial fibrillation patients. The aim of this review is to explore the impact that existing atrial fibrillation treatment strategies may have on cognition and the putative mechanisms linking the two conditions. This review examines how components of the 'Atrial Fibrillation Better Care pathway' (stroke risk reduction, rhythm control, rate control, and risk factor management) may influence the trajectory of atrial fibrillation-associated cognitive decline. The requirements for further prospective studies to understand the mechanistic link between atrial fibrillation and dementia and to develop treatment strategies targeted towards the prevention of atrial fibrillation-associated cognitive decline, are highlighted.

Indexed as

anticoagulationatrial fibrillationcognitive declinedementiarate controlrhythm control

Identifiers

PMID37176490
PMCPMC10179566
OpenAlexW4366829215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.