Evidence map›Paper›PMID 37176166›Full record

ArticleInternational journal of molecular sciences2023

Blood Metabolite Profiling of Antarctic Expedition Members: An

Laura Del Coco, Marco Greco, Alessandra Inguscio, Anas Munir, Antonio Danieli, Luca Cossa, Debora Musarò, Maria Rosaria Coscia, Francesco Paolo Fanizzi, Michele Maffia

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laura Del CocoDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-4805-7538
Marco GrecoDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-9228-1158
Alessandra InguscioDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-3122-1186
Anas MunirDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-3043-8233
Antonio DanieliDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.
Luca CossaDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-1478-7268
Debora MusaròDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.
Maria Rosaria CosciaInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Via P. Castellino 111, 80131 Naples, Italy.
Francesco Paolo FanizziDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-3073-5772
Michele MaffiaDepartment of Biological and Environmental Science and Technology, University of Salento, Via Lecce-Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-0665-4534
University of Salento · ITNational Research Council · IT

Funding

Ministry of Education, Universities and Research PNRA16_00047 project-Line A2Ministry of Education, Universities and Research PNRA18_0 0071_Prot. 20891.21-11-2019
6 · The paper itself

Abstract

Serum samples from eight participants during the XV winter-over at Concordia base (Antarctic expedition) collected at defined time points, including predeparture, constituted the key substrates for a specific metabolomics study. To ascertain acute changes and chronic adaptation to hypoxia, the metabolic profiles of the serum samples were analyzed using NMR spectroscopy, with principal components analysis (PCA) followed by partial least squares and orthogonal partial least squares discriminant analyses (PLS-DA and OPLS-DA) used as supervised classification methods. Multivariate data analyses clearly highlighted an adaptation period characterized by an increase in the levels of circulating glutamine and lipids, mobilized to supply the body energy needs. At the same time, a reduction in the circulating levels of glutamate and

Indexed as

ExpeditionsAntarctic RegionsHumansMagnetic Resonance SpectroscopyMetabolomeMetabolomicsadaptationAntarcticaConcordia basehypoxiametabolomicsNMRwinter-over

Identifiers

PMID37176166
PMCPMC10179003
OpenAlexW4376630724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.