Evidence map›Paper›PMID 37176165›Full record

ArticleInternational journal of molecular sciences2023

GABA

Gerald Ikemefuna Nwosu, Wangzhen Shen, Kirill Zavalin, Sarah Poliquin, Karishma Randhave, Carson Flamm, Marshall Biven, Katherine Langer, Jing-Qiong Kang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. GABASynapse (New York, N.Y.) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. 4-Phenylbutyrate Rescue inbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  12. Clinical trials for Lennox-Gastaut syndrome: Challenges and priorities.Annals of clinical and translational neurology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gerald Ikemefuna NwosuDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.ORCID 0000-0001-6697-0585
Wangzhen ShenDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kirill ZavalinDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sarah PoliquinDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-4151-3991
Karishma RandhaveDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Carson FlammDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-6070-0864
Marshall BivenDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Katherine LangerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jing-Qiong KangDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Vanderbilt University Medical Center · USVanderbilt University · USMeharry Medical College · US

Funding

THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Promoting Protein Trafficking with 4-phenylbutyrate to Treat Genetic EpilepsyR01NS121718 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jing-Qiong Kang · 2022 to 2026
$2.2M
Altered synapse formation and function in a novel Dravet syndrome mouse modelR01NS082635 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KANG, JING-QIONG · 2013 to 2017
$1.7M
NICHD NIH HHS P50 HD103537NIGMS NIH HHS R25 GM059994NINDS NIH HHS NS082635NINDS NIH HHS NS121718NINDS NIH HHS R01 NS082635NINDS NIH HHS R01 NS121718
6 · The paper itself

Abstract

Lennox-Gastaut Syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types, electroencephalogram (EEG) patterns, and cognitive decline. Its etiology has a prominent genetic component, including variants in

Indexed as

EpilepsyLennox Gastaut SyndromeAnimalsElectroencephalographyFemalegamma-Aminobutyric AcidMaleMiceMice, Inbred C57BLMutationReceptors, GABA-ASeizuresgamma-Aminobutyric AcidReceptors, GABA-Adevelopmental epileptic encephalopathyepilepsyGABRB3knock-in mouse model

Identifiers

PMID37176165
PMCPMC10179596
OpenAlexW4376629883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.