Evidence map›Paper›PMID 37176143›Full record

ArticleInternational journal of molecular sciences2023

Analysis of Circulating Tumor DNA in Synchronous Metastatic Colorectal Cancer at Diagnosis Predicts Overall Patient Survival.

José María Sayagués, Juan Carlos Montero, Andrea Jiménez-Pérez, Sofía Del Carmen, Marta Rodríguez, Rosario Vidal Tocino, Enrique Montero, Julia Sanz, Mar Abad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

José María SayaguésDepartment of Pathology and IBSAL, University Hospital of Salamanca, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0582-3500
Juan Carlos MonteroDepartment of Pathology and IBSAL, University Hospital of Salamanca, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-4773-053X
Andrea Jiménez-PérezDepartment of Pathology and IBSAL, University Hospital of Salamanca, University of Salamanca, 37007 Salamanca, Spain.
Sofía Del CarmenDepartment of Pathology, University Hospital of Marqués de Valdecilla, 39008 Santander, Spain.
Marta RodríguezDepartment of Pathology and IBSAL, University Hospital of Salamanca, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-8544-6201
Rosario Vidal TocinoDepartment of Oncology and IBSAL, University Hospital of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-0588-2001
Enrique MonteroDepartment of Pathology, University Hospital of Zamora, 49071 Zamora, Spain.
Julia SanzDepartment of Pathology, Puerto Real University Hospital, 11510 Cadiz, Spain.
Mar AbadDepartment of Pathology and IBSAL, University Hospital of Salamanca, University of Salamanca, 37007 Salamanca, Spain.
Universidad de Salamanca · ESHospital Universitario Puerto Real · ESHospital Virgen de la Concha · ESMarqués de Valdecilla University Hospital · ES

Funding

Gerencia Regional de Salud de la Junta de Castilla y León GRS 2626/A/22
6 · The paper itself

Abstract

Sporadic colorectal cancer (sCRC) initially presents as metastatic tumors in 25-30% of patients. The 5-year overall survival (OS) in patients with metastatic sCRC is 50%, falling to 10% in patients presenting with synchronous metastatic disease (stage IV). In this study, we systematically analyzed the mutations of

Indexed as

Circulating Tumor DNAColonic NeoplasmsColorectal NeoplasmsRectal NeoplasmsBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesDNA Mutational AnalysisHumansMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Biomarkers, TumorCirculating Tumor DNAClass I Phosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)anti-EGFRanti-VEGFBRAFKRASliquid biopsyNRASPIK3CAsynchronous metastatic colorectal cancer

Identifiers

PMID37176143
PMCPMC10179090
OpenAlexW4376631060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.