ReviewInternational journal of molecular sciences2023
Current Levels of Environmental Exposure to Cadmium in Industrialized Countries as a Risk Factor for Kidney Damage in the General Population: A Comprehensive Review of Available Data.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Dose-response relationship of cadmium and pancreatic cancer risk: a meta-analysis.Occupational and environmental medicine · 2025Pooled it
- Article
- Potentially Toxic Element (PTE) Contamination in Raw Cow Milk: Insights into Concentration Levels and Dietary Exposure Risk Assessment.Biological trace element research · 2026Article
- Role of NOX4 and GSH in Cadmium-Induced Renal Redox Homeostatic Dysregulation of Rats and APO Intervention Effect Study.Biological trace element research · 2026Article
- Evaluation of Toxic Elements in Commercial Dried Mushrooms from the Polish Market: Exposure Assessment and Health Risk Characterization.Molecules (Basel, Switzerland) · 2026Article
- Article
- Review
- Cadmium exposure as a contributing factor to hepato-renal injury in apparently healthy active cigarette smokers in buea-cameroon.PloS one · 2026Article
- Oral microbiome alterations and their association with long-term heavy metal exposure and early health effects.Journal of oral microbiology · 2026Article
- Role for plant foods in kidney health among middle-aged individuals environmentally exposed to cadmium and lead.PloS one · 2026Article
- A Narrative Review of Metallomic Studies: Revealing the Toxic Metal Burden in Tobacco Smokers.International journal of molecular sciences · 2025Review
- Evaluating the impact of environmental metal mixtures on chronic kidney disease risk: Insights from the National Health and Nutrition Examination Survey 2011-2016.The Journal of international medical research · 2025Article
- Relationship Between Urinary Copper, Zinc, and Cadmium and Kidney Damage Biomarkers in Young People.International journal of molecular sciences · 2025Article
- Assessing Heavy Metal Contamination in Commonly Used Fertilizers for Polyculture Fish Ponds and Its Implications for Human Health: A Comprehensive Investigation.Biological trace element research · 2025Article
- Screening of bioactive components inToxicology reports · 2025Article
- The association between urinary cadmium exposure levels and overactive bladder syndrome in the U.S. adults from NHANES database.Scientific reports · 2025Article
- Urinary βJournal of xenobiotics · 2025Article
- Antioxidative Function of Zinc and Its Protection Against the Onset and Progression of Kidney Disease Due to Cadmium.Biomolecules · 2025Review
- Albuminuria in People Chronically Exposed to Low-Dose Cadmium Is Linked to Rising Blood Pressure Levels.Toxics · 2025Article
- The association between cadmium exposure and lung cancer risk: A protocol for systematic review and meta-analysis.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing number of reports indicating unfavorable outcomes for human health upon environmental exposure to cadmium (Cd) have focused attention on the threat to the general population posed by this heavy metal. The kidney is a target organ during chronic Cd intoxication. The aim of this article was to critically review the available literature on the impact of the current levels of environmental exposure to this xenobiotic in industrialized countries on the kidney, and to evaluate the associated risk of organ damage, including chronic kidney disease (CKD). Based on a comprehensive review of the available data, we recognized that the observed adverse effect levels (NOAELs) of Cd concentration in the blood and urine for clinically relevant kidney damage (glomerular dysfunction) are 0.18 μg/L and 0.27 μg/g creatinine, respectively, whereas the lowest observed adverse effect levels (LOAELs) are >0.18 μg/L and >0.27 μg/g creatinine, respectively, which are within the lower range of concentrations noted in inhabitants of industrialized countries. In conclusion, the current levels of environmental exposure to Cd may increase the risk of clinically relevant kidney damage, resulting in, or at least contributing to, the development of CKD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.