ArticleInternational journal of molecular sciences2023
Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Systemic immune-inflammation index as a novel biomarker for metabolic syndrome: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Systemic inflammatory indices and glucose homeostasis in children with obesity: evidence from oral glucose tolerance testing.European journal of pediatrics · 2026Article
- Uncoupling Systemic Inflammation from Body Mass Index: The Unseen Role of Visceral Adiposity and Metabolic Phenotypes-A Subgroup Analysis of the Nationwide OBREDI-TR Cohort.Journal of clinical medicine · 2026Article
- Associations of systemic inflammatory indices and metabolically healthy vs. unhealthy obesity in children.Italian journal of pediatrics · 2026Article
- Lipid metabolism related inflammation modulates ocular growth in a high-fat diet guinea pig model.Journal of translational medicine · 2026Article
- Obesity, Metabolic Syndrome and MASLD in Children: Inflammation as the Missing Link-A Short Narrative Review.Life (Basel, Switzerland) · 2026Review
- Evaluation of novel inflammatory biomarkers in overweight, obese, and morbidly obese children: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Association Between Complete Blood Cell Count (CBC)-Derived Inflammatory Markers and Natural Killer Cell Activity: A Cross-Sectional Study.Journal of inflammation research · 2026Article
- Synergistic Impact of Obesity and PCOS on Immune Dysregulation: A Review of Systemic and Local Inflammatory Profiles.International journal of women's health · 2026Review
- Correlation between serum prolactin and the systemic immune-inflammation index in diabetic kidney disease: a cross-sectional study.Frontiers in endocrinology · 2026Article
- The association between systemic immune-inflammatory index and cardiac biomarkers among US population: a cross-sectional study.European journal of medical research · 2025Article
- Dietary inflammatory index and blood inflammatory markers in relation to dyslipidemia: A cross-sectional NHANES study (2009-2018).Asia Pacific journal of clinical nutrition · 2025Article
- Systemic Inflammation Indices, Chemokines, and Metabolic Markers in Perimenopausal Women.Nutrients · 2025Article
- Predictors of response to accelerated rTMS in the treatment of treatment-resistant depression.European archives of psychiatry and clinical neuroscience · 2025Article
- Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome.European journal of medical research · 2025Article
- Article
- Predicting overactive bladder from inflammatory markers: A machine learning approach using NHANES 2005-2020.Biomolecules & biomedicine · 2025Article
- Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study.BMC psychiatry · 2025Article
- Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA).Cardiovascular diabetology · 2025Article
- Systemic immune inflammation index (SII) assessment as a potential tool against childhood hypertension.Pediatric research · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obesity represents a worldwide concern as many countries have reported an increase in its incidence, with possible cardiovascular long-term implications. The mechanism that links cardiovascular disease to obesity is related to low-grade inflammation. We designed this study to investigate the diagnostic utility of inflammatory indices (NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index) in obese children with metabolic syndrome (MetS) and their relationship with cardiometabolic risk biomarkers, such as the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C). A total of 191 obese children from one large Romanian reference center was included in the study. Patients were classified in two groups according to the presence (MetS group) or absence (non-MetS group) of metabolic syndrome. According to our results, the SII index proved to have diagnostic value in distinguishing MetS patients among children with obesity (AUC = 0.843, a sensitivity of 0.83, and a specificity of 0.63). Furthermore, the SII was positively associated with cardiometabolic risk biomarkers (HOMA-IR,
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