Evidence map›Paper›PMID 37176099›Full record

ArticleInternational journal of molecular sciences2023

Co-Delivery of Ylang Ylang Oil of

Nada K Sedky, Nour M Abdel-Kader, Marwa Y Issa, Manal M M Abdelhady, Samir N Shamma, Udo Bakowsky, Sherif Ashraf Fahmy

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  6. Biologically Active Compounds of Malaysian Medicinal and Aromatic Plants.Progress in the chemistry of organic natural products · 2025
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  10. Liposomal Formulations of Metallodrugs for Cancer Therapy.International journal of molecular sciences · 2024
    Review
  11. Article
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  19. Nedaplatin/Pharmaceutics · 2023
    Article
  20. RSC advances · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Nada K SedkyDepartment of Biochemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, R5 New Garden City, New Administrative Capital, Cairo 11835, Egypt.ORCID 0000-0002-2359-3799
Nour M Abdel-KaderDepartment of Biochemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, R5 New Garden City, New Administrative Capital, Cairo 11835, Egypt.
Marwa Y IssaDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.ORCID 0000-0002-2181-7090
Manal M M AbdelhadyClinical Pharmacy Department, Faculty of Pharmacy, Badr University, Cairo 11829, Egypt.
Samir N ShammaInstitute of Global Health and Human Ecology, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt.
Udo BakowskyDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.ORCID 0000-0002-3895-0453
Sherif Ashraf FahmyDepartment of Chemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, R5 New Garden City, New Administrative Capital, Cairo 11835, Egypt.ORCID 0000-0003-3056-8281
Ain Shams University · EGAmerican University in Cairo · EGBadr University in Cairo · EGCairo University · EGPhilipps University of Marburg · DE

Funding

Royal Society of Chemistry R22-3870733873
6 · The paper itself

Abstract

Smart pH-responsive niosomes loaded with either Oxaliplatin (Ox), Ylang ylang essential oil (Y-oil), or co-loaded with both compounds (Ox-Y) (Ox@NSs, Y@NSs, and Ox-Y@NSs, respectively) were formulated utilizing the thin film method. The developed nanocontainers had a spherical morphology with mean particle sizes lower than 170 nm and showed negative surface charges, high entrapment efficiencies, and a pH-dependent release over 24 h. The prepared pH-responsive niosomes' cytotoxicity was tested against the invasive triple-negative breast cancer (MDA-MB-231) cells, compared to free OX and Y-oil. All niosomal formulations loaded with Ox and/or Y-oil significantly improved cytotoxic activity relative to their free counterparts. The Ox-Y@NSs demonstrated the lowest IC50 (0.0002 µg/mL) when compared to Ox@NSs (0.006 µg/mL) and Y@NSs (18.39 µg/mL) or unloaded Ox (0.05 µg/mL) and Y-oil (29.01 µg/mL)

Indexed as

Antineoplastic AgentsCanangaOils, VolatileTriple Negative Breast NeoplasmsCaspase 7HumansHydrogen-Ion ConcentrationLiposomesOxaliplatinPlant OilsAntineoplastic AgentsCaspase 7LiposomesOils, VolatileOxaliplatinPlant Oilsapoptosiscytotoxicityessential oilsintrinsic pathwayinvasive breast cancerniosomesoxaliplatinplatinum-based anticancer drugs

Identifiers

PMID37176099
PMCPMC10179110
OpenAlexW4376630315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.