Evidence map›Paper›PMID 37175987›Full record

ArticleInternational journal of molecular sciences2023

Genetic Profiling of Sodium Channels in Diabetic Painful and Painless and Idiopathic Painful and Painless Neuropathies.

Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Ślęczkowska, Patrick Lindsey, Bianca T A de Greef, Janneke G J Hoeijmakers, Erika Salvi, Ingemar S J Merkies, Maryam Ferdousi and 14 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genetic Variants Influence the Development of Diabetic Neuropathy.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 8 countries.

Rowida AlmomaniDepartment of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0000-0003-1524-4051
Maurice SopacuaDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.ORCID 0000-0001-8132-1532
Margherita MarchiNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.ORCID 0000-0002-5098-8534
Milena ŚlęczkowskaClinical Genomics Unit, Department of Genetics and Cell Biology, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-7419-523X
Patrick LindseyClinical Genomics Unit, Department of Genetics and Cell Biology, Maastricht University, 6229 ER Maastricht, The Netherlands.
Bianca T A de GreefDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.
Janneke G J HoeijmakersDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.ORCID 0000-0001-6940-0027
Erika SalviNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.ORCID 0000-0002-2724-2291
Ingemar S J MerkiesDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.
Maryam FerdousiInstitute of Cardiovascular Sciences, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9P, UK.
Rayaz A MalikInstitute of Cardiovascular Sciences, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9P, UK.ORCID 0000-0002-7188-8903
Dan ZieglerGerman Diabetes Centre, 40225 Düsseldorf, Germany.ORCID 0000-0001-8956-3552
Kasper W J DerksDepartment of Clinical Genetics, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.
Gidon BoenhofInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, 40225 Düsseldorf, Germany.
Filippo Martinelli-BoneschiLaboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Daniele CazzatoNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.
Raffaella LombardiNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.
Sulayman Dib-HajjDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.
Stephen G WaxmanDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-5718-7177
Hubert J M SmeetsClinical Genomics Unit, Department of Genetics and Cell Biology, Maastricht University, 6229 ER Maastricht, The Netherlands.
Monique M GerritsDepartment of Clinical Genetics, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-9503-9404
Catharina G FaberDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-2467-067X
Giuseppe LauriaNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.
On Behalf Of The Propane Study Group
Maastricht University Medical Centre · NLFondazione IRCCS Istituto Neurologico Carlo Besta · ITMaastricht University · NLDeutsches Diabetes-Zentrum e.V. · DEManchester Academic Health Science Centre · GBYale University · USJordan University of Science and Technology · JOUniversity of Milan · IT

Funding

Molecule-to-Man Pain Network, European Commission Multi-Center Collaborative Projects through the European Union's Horizon 2020 research and innovation program 721841the European Union seventh framework programme for the PROPANE study 602273
6 · The paper itself

Abstract

Neuropathic pain is a frequent feature of diabetic peripheral neuropathy (DPN) and small fiber neuropathy (SFN). Resolving the genetic architecture of these painful neuropathies will lead to better disease management strategies, counselling and intervention. Our aims were to profile ten sodium channel genes (SCG) expressed in a nociceptive pathway in painful and painless DPN and painful and painless SFN patients, and to provide a perspective for clinicians who assess patients with painful peripheral neuropathy. Between June 2014 and September 2016, 1125 patients with painful-DPN (

Indexed as

Diabetes MellitusDiabetic NeuropathiesNeuralgiaSmall Fiber NeuropathyHumansNAV1.7 Voltage-Gated Sodium ChannelPainPeripheral Nervous System DiseasesSodium ChannelsNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanSodium Channelsdiabetic neuropathymolecular inversion probesneuropathic painnext generation sequencingsmall fiber neuropathysodium channel genes variants

Identifiers

PMID37175987
PMCPMC10179245
OpenAlexW4376630545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.