Evidence map›Paper›PMID 37175969›Full record

ReviewInternational journal of molecular sciences2023

Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review.

Nneamaka Iwobi, Nicole R Sparks

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Effects of Endocrine-Disrupting Chemicals on Bone Health.Endocrinology and metabolism (Seoul, Korea) · 2024
    Review
  10. Review
  11. Imprinting and Reproductive Health: A Toxicological Perspective.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nneamaka IwobiDepartment of Pharmaceutical Sciences, School of Pharmacy, University of California, Irvine, CA 92697, USA.ORCID 0009-0009-0504-388X
Nicole R SparksDepartment of Occupational and Environmental Health, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-6176-7895
University of California, Irvine · US

Funding

Analysis of environmentally-sensitive epigenetic machinery during osteogenic differentiationR00ES032486 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SPARKS, NICOLE RENEE · 2022 to 2024
$956k
NIEHS NIH HHS R00 ES032486NIEHS NIH HHS R00ES032486
6 · The paper itself

Abstract

Hormones are indispensable for bone development, growth, and maintenance. While many of the genes associated with osteogenesis are well established, it is the recent findings in endocrinology that are advancing the fields of bone biology and toxicology. Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. Here, we report recent discoveries describing key hormone pathways involved in osteogenesis and the EDCs that alter these pathways. EDCs can lead to bone morphological changes via altering hormone receptors, signaling pathways, and gene expression. The objective of this review is to highlight the recent discoveries of the harmful effects of environmental toxicants on bone formation and the pathways impacted. Understanding the mechanisms of how EDCs interfere with bone formation contributes to providing a comprehensive toxicological profile of a chemical.

Indexed as

Endocrine DisruptorsEndocrinologyEndocrine SystemHormonesSignal TransductionEndocrine DisruptorsHormonesbone defectsendocrine-disrupting chemicalsendocrine toxicityhormonesosteoblastsosteogenesis

Identifiers

PMID37175969
PMCPMC10179611
OpenAlexW4376630947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.