Evidence map›Paper›PMID 37175953›Full record

ArticleInternational journal of molecular sciences2023

1,5-Anhydro-D-Fructose Exhibits Satiety Effects via the Activation of Oxytocin Neurons in the Paraventricular Nucleus.

Masanori Nakata, Yuto Yamaguchi, Hikaru Monnkawa, Midori Takahashi, Boyang Zhang, Putra Santoso, Toshihiko Yada, Ikuro Maruyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Masanori NakataDepartment of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan.
Yuto YamaguchiDepartment of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan.
Hikaru MonnkawaDepartment of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan.
Midori TakahashiDepartment of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan.
Boyang ZhangDepartment of Physiology, School of Medicine, Wakayama Medical University, Kimiidare 811-1, Wakayama 641-8509, Japan.
Putra SantosoDepartment of Physiology, Division of Integrative Physiology, School of Medicine, Jichi Medical University, Shimotsuke 329-0498, Japan.
Toshihiko YadaCenter for Integrative Physiology, Kansai Electric Power Medical Research Institute, Kyoto 604-8436, Japan.
Ikuro MaruyamaDepartment of Systems Biology in Thromboregulation, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima 890-8520, Japan.
Wakayama Medical University · JPJichi Medical University · JPKagoshima University · JPKansai Electric Power (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,5-Anhydro-D-fructose (1,5-AF) is a bioactive monosaccharide that is produced by the glycogenolysis in mammalians and is metabolized to 1,5-anhydro-D-glucitol (1,5-AG). 1,5-AG is used as a marker of glycemic control in diabetes patients. 1,5-AF has a variety of physiological activities, but its effects on energy metabolism, including feeding behavior, are unclarified. The present study examined whether 1,5-AF possesses the effect of satiety. Peroral administration of 1,5-AF, and not of 1,5-AG, suppressed daily food intake. Intracerebroventricular (ICV) administration of 1,5-AF also suppressed feeding. To investigate the neurons targeted by 1,5-AF, we investigated c-Fos expression in the hypothalamus and brain stem. ICV injection of 1,5-AF significantly increased c-Fos positive oxytocin neurons and mRNA expression of oxytocin in the paraventricular nucleus (PVN). Moreover, 1,5-AF increased cytosolic Ca

Indexed as

OxytocinParaventricular Hypothalamic NucleusAnimalsFructoseHypothalamusMammalsMiceNeurons1,5-anhydrofructoseFructoseOxytocin1,5-Anhydro-D-fructosefeeding behavioroxytocinPVN

Identifiers

PMID37175953
PMCPMC10179633
OpenAlexW4376630427

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.