Evidence map›Paper›PMID 37175858›Full record

ArticleInternational journal of molecular sciences2023

Cirrhotic Cardiomyopathy Following Bile Duct Ligation in Rats-A Matter of Time?

Moritz Uhlig, Marc Hein, Moriz A Habigt, René H Tolba, Till Braunschweig, Marius J Helmedag, Melissa Arici, Alexander Theißen, Axel Klinkenberg, Uwe Klinge and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Combining sorafenib andIranian journal of basic medical sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Experimental Liver Cirrhosis Inhibits Restenosis after Balloon Angioplasty.International journal of molecular sciences · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Moritz UhligDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-6533-6515
Marc HeinDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-9436-7353
Moriz A HabigtDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1445-608X
René H TolbaInstitute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Till BraunschweigDepartment of Pathology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-9166-2912
Marius J HelmedagDepartment of General, Visceral and Transplantation Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-8914-7978
Melissa AriciLuisenhospital, 52064 Aachen, Germany.
Alexander TheißenDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Axel KlinkenbergLuisenhospital, 52064 Aachen, Germany.
Uwe KlingeDepartment of General, Visceral and Transplantation Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Mare MechelinckDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-8928-338X
RWTH Aachen University · DELuisenhospital Aachen · DE

Funding

B.Braun-Stiftung BBST-D-18-00022RWTH Aachen University Clinician Scientist "Starter"RWTH Aachen University ROTATION program
6 · The paper itself

Abstract

Cirrhotic patients often suffer from cirrhotic cardiomyopathy (CCM). Previous animal models of CCM were inconsistent concerning the time and mechanism of injury; thus, the temporal dynamics and cardiac vulnerability were studied in more detail. Rats underwent bile duct ligation (BDL) and a second surgery 28 days later. Cardiac function was assessed by conductance catheter and echocardiography. Histology, gene expression, and serum parameters were analyzed. A chronotropic incompetence (P

Indexed as

CardiomyopathiesLiver CirrhosisAnimalsBile DuctsDisease Models, AnimalFibrosisLigationLiverMyocardiumRatsbile duct ligationchronic liver failurecirrhotic cardiomyopathyfibrosisliver cirrhosismitochondropathymyocardial failurerodent modelsecond hit

Identifiers

PMID37175858
PMCPMC10249007
OpenAlexW4368375870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.