Evidence map›Paper›PMID 37175812›Full record

ArticleInternational journal of molecular sciences2023

A Novel Role for UNC119 as an Enhancer of Synaptic Transmission.

Katherine E Fehlhaber, Anurima Majumder, Kimberly K Boyd, Khris G Griffis, Nikolai O Artemyev, Gordon L Fain, Alapakkam P Sampath

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katherine E FehlhaberDepartment of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.
Anurima MajumderMolecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Kimberly K BoydMolecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Khris G GriffisDepartment of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-6909-9286
Nikolai O ArtemyevMolecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Gordon L FainDepartment of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.
Alapakkam P SampathDepartment of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-0785-9577
University of California, Los Angeles · USUniversity of Iowa · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
REGULATION OF ROD CYCLIC GMP PHOSPHODIESTERASER01EY010843 · NEI · UNIVERSITY OF IOWA · PI Nikolai O Artemyev · 1995 to 2026
$8.9M
MOLECULAR MECHANISM OF PHOTORECEPTOR G PROTEIN SIGNALINGR01EY012682 · NEI · UNIVERSITY OF IOWA · PI ARTEMYEV, NIKOLAI O · 2000 to 2022
$7.5M
Molecular Basis of Photoreceptor WiringR01EY028033 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov, Alapakkam P Sampath · 2017 to 2026
$4.6M
Functional characteristics of rod pathways in the retinaR01EY017606 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SAMPATH, ALAPAKKAM P · 2006 to 2015
$3.7M
Analyses of retinal circuits after rod rescue in a mouse model of human blindnessR01EY027193 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JEANNIE, FIELD, GREGORY DARIN · 2016 to 2020
$2.7M
Molecular Mechanisms of Photoreceptor AdaptationR01EY029817 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMPATH, ALAPAKKAM P · 2019 to 2023
$2.1M
MOLECULAR GENETICS OF EARLY EYE DEVELOPMENTZ01EY000311 · NEI · NATIONAL EYE INSTITUTE · PI TOMAREV, STANISLAV I · 1996 to 2008
$941k
PHYSIOLOGY OF PHOTORECEPTORSR37EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAIN, GORDON LEE · 1990 to 1999
–
Intramural NIH HHS Z01 EY000311NEI NIH HHS P30 EY000331NEI NIH HHS P30 EY00311NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY010843NEI NIH HHS R01 EY012682NEI NIH HHS R01 EY017606NEI NIH HHS R01 EY01844NEI NIH HHS R01 EY027193NEI NIH HHS R01 EY029817NEI NIH HHS R01 EY10843NEI NIH HHS R01 EY12682NEI NIH HHS R01 EY28033NEI NIH HHS R01 EY29817NEI NIH HHS R37 EY001844
6 · The paper itself

Abstract

Mammalian UNC119 is a ciliary trafficking chaperone highly expressed in the inner segment of retinal photoreceptors. Previous research has shown that UNC119 can bind to transducin, the synaptic ribbon protein RIBEYE, and the calcium-binding protein CaBP4, suggesting that UNC119 may have a role in synaptic transmission. We made patch-clamp recordings from retinal slices in mice with the

Indexed as

Synaptic TransmissionTransducinAdaptor Proteins, Signal TransducingAnimalsGlutamatesMammalsMiceRetinaSynapsesAdaptor Proteins, Signal TransducingGlutamatesTransducinUnc119 protein, mouseadaptationbipolar cellretinasensitivitysynaptic transmissionUNC119

Identifiers

PMID37175812
PMCPMC10178850
OpenAlexW4367627067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.