Evidence map›Paper›PMID 37175734›Full record

ArticleInternational journal of molecular sciences2023

Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F).

Yoo-Bin Lee, Vitchan Kim, Sung-Gyu Lee, Gyu-Hyeong Lee, Changmin Kim, Eunseo Jeong, Donghak Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yoo-Bin LeeDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.ORCID 0009-0009-1697-8920
Vitchan KimDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.
Sung-Gyu LeeDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.
Gyu-Hyeong LeeDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.
Changmin KimDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.
Eunseo JeongDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.
Donghak KimDepartment of Biological Sciences, Konkuk University, Seoul 05025, Republic of Korea.ORCID 0000-0002-4421-7215
Konkuk University · KR

Funding

National Research Foundation of Korea NRF-2019R1A2C1004722
6 · The paper itself

Abstract

The human cytochrome P450 2C8 is responsible for the metabolism of various clinical drugs as well as endogenous fatty acids. Allelic variations can significantly influence the metabolic outcomes. In this study, we characterize the functional effects of four nonsynonymous single nucleotide polymorphisms *15, *16, *17, and *18 alleles recently identified in cytochrome P450 2C8. The recombinant allelic variant enzymes V181I, I244V, I331T, and L361F were successfully expressed in

Indexed as

Fatty AcidsPolymorphism, Single NucleotideAllelesArachidonic AcidHumansKineticsPaclitaxelArachidonic AcidFatty AcidsPaclitaxelallelic variantarachidonic acidcytochrome P450mass spectrometryP450 2C8paclitaxel

Identifiers

PMID37175734
PMCPMC10178350
OpenAlexW4367311858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.