Evidence map›Paper›PMID 37175717›Full record

SynthesisInternational journal of molecular sciences2023

Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?

Antonio José Cabrera-Serrano, José Manuel Sánchez-Maldonado, Rob Ter Horst, Angelica Macauda, Paloma García-Martín, Yolanda Benavente, Stefano Landi, Alyssa Clay-Gilmour, Yasmeen Niazi, Blanca Espinet and 32 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 8 countries.

Antonio José Cabrera-SerranoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, 18016 Granada, Spain.ORCID 0000-0003-0346-7960
José Manuel Sánchez-MaldonadoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, 18016 Granada, Spain.ORCID 0000-0002-4651-3675
Rob Ter HorstCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Angelica MacaudaGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Paloma García-MartínHospital Campus de la Salud, PTS, 18016 Granada, Spain.
Yolanda BenaventeCatalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0003-1422-4614
Stefano LandiDepartment of Biology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-8364-6357
Alyssa Clay-GilmourDepartment of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Greenville, SC 29208, USA.
Yasmeen NiaziDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Blanca EspinetMolecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0002-4294-8145
Juan José Rodríguez-SevillaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-4741-7925
Eva María PérezHospital Campus de la Salud, PTS, 18016 Granada, Spain.
Rossana MaffeiDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.ORCID 0000-0002-3518-2006
Gonzalo BlancoMolecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0001-6557-3764
Matteo GiaccheriniDepartment of Biology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-0363-6632
James R CerhanDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Roberto MarascaDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.ORCID 0000-0002-6431-6878
Miguel Ángel López-NevotImmunology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain.ORCID 0000-0002-3465-6062
Tzu Chen-LiangHematology Department, Morales Meseguer University Hospital, 30008 Murcia, Spain.
Hauke ThomsenMSB Medical School Berlin, D-14197 Berlin, Germany.ORCID 0000-0001-5951-3116
Irene GámezHematology Department, Morales Meseguer University Hospital, 30008 Murcia, Spain.
Daniele CampaDepartment of Biology, University of Pisa, 56126 Pisa, Italy.
Víctor MorenoCatalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.ORCID 0000-0002-2818-5487
Silvia de SanjoséCatalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Rafael Marcos-GrageraConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), University of Barcelona, 08908 Barcelona, Spain.ORCID 0000-0001-9824-3657
María García-ÁlvarezDepartment of Hematology, University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Institute of Salamanca-IBMCC (USAL-CSIC), 37007 Salamanca, Spain.
Trinidad Dierssen-SotosConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), University of Barcelona, 08908 Barcelona, Spain.ORCID 0000-0002-6127-0077
Andrés JerezDepartment of Hematology, Experimental Hematology Unit, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0002-2079-6638
Aleksandra ButrymDepartment of Cancer Prevention and Therapy, Medical University of Wrocław, 50-556 Wrocław, Poland.ORCID 0000-0002-8199-2018
Aaron D NormanDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Mario LuppiDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.
Susan L SlagerDivision of Computational Genomics, Mayo Clinic, Rochester, MN 85054, USA.
Kari HemminkiDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.ORCID 0000-0002-2769-3316
Yang LiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4022-7341
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.
Delphine CasabonneCatalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.
Miguel AlcocebaDepartment of Hematology, University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Institute of Salamanca-IBMCC (USAL-CSIC), 37007 Salamanca, Spain.ORCID 0000-0002-3819-4846
Anna PuiggrosMolecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0001-9627-4978
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Asta FörstiDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.ORCID 0000-0002-9857-4728
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-4261-4583
Juan SainzGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, 18016 Granada, Spain.ORCID 0000-0002-9355-2423
German Cancer Research Center · DEInstitut d'Investigació Biomédica de Bellvitge · ESHospital Del Mar · ESUniversity of Modena and Reggio Emilia · ITUniversity of Pisa · ITHospital General Universitario Morales Meseguer · ESInstituto de Investigación Biomédica de Salamanca · ESInstituto de Investigación Biosanitaria de Granada · ESMayo Clinic in Florida · USParque Tecnológico de la Salud · ESAustrian Academy of Sciences · ATGeneralitat de Catalunya · ESHospital Universitario Virgen de las Nieves · ESMayo Clinic · USMSB Medical School Berlin · DENational Institutes of Health · USRadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · USUniversidad de Cantabria · ESUniversidad de Granada · ES

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Molecular Epidemiology of NHL and CLLR01CA092153 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R · 2003 to 2012
$6.7M
NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA092153
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for CLL could influence overall survival (OS) and disease progression, defined as time to first treatment (TTFT) in a cohort of 1039 CLL cases ascertained through the CRuCIAL consortium. Although this is the largest study assessing the effect of GWAS-identified susceptibility variants for CLL on OS, we only found a weak association of ten single nucleotide polymorphisms (SNPs) with OS (

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellAdultDisease ProgressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk Factorschronic lymphocytic leukemiagenetic variantsoverall survivalpolygenic risk scoresusceptibilityTTFT

Identifiers

PMID37175717
PMCPMC10178669
OpenAlexW4367311543

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.