ArticleInternational journal of molecular sciences2023
Poly-D,L-Lactic Acid Stimulates Angiogenesis and Collagen Synthesis in Aged Animal Skin.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 69 citations in OpenAlex.
- Prospective Intraindividual Split-face Histological Comparison of Poly-d,l-lactic Acid and Calcium Hydroxylapatite Skin Boosters Using Stem Cell Markers.Plastic and reconstructive surgery. Global open · 2026Article
- Investigation of Vascular Behaviour and Tissue Response Following Intra-Arterial Injection of Poly D,L-Lactic Acid with Hyaluronic Acid Hybrid Biostimulators (JuvelookJournal of functional biomaterials · 2026Article
- Oxidative Stress-Mediated Mitochondrial Dysfunction Drives Genistein-Induced Apoptosis in TM4 Sertoli and ELT3 Leiomyoma Cells.Journal of xenobiotics · 2026Article
- Immunomodulatory Effects of Poly-D,L-Lactic Acid on LL-37-Driven Rosacea-like Inflammation via Suppression of mTORC1 Signaling.International journal of molecular sciences · 2026Article
- Clavicular Augmentation With Poly-d,l-lactic Acid (Juvelook GLAM) using Cannula.Plastic and reconstructive surgery. Global open · 2026Article
- Hybrid Biostimulator and Hyaluronic Acid Injectable for Tear Trough Rejuvenation.Aesthetic plastic surgery · 2026Article
- Article
- Hybrid Poly-D,L-Lactic Acid and Autologous Fat Transfer for Forehead Augmentation.Aesthetic plastic surgery · 2026Article
- Poly-D,L-Lactic Acid Filler Restores Hair Thickness and Shine by Ameliorating Age-Associated Follicular Decline.International journal of molecular sciences · 2026Article
- Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.Nature communications · 2026Article
- The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics.Frontiers in immunology · 2026Review
- Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin.Cells · 2025Article
- Evaluation of Bio-Stimulation Effects of Various Dermal Fillers: Hyaluronic Acid-Based Polynucleotides and Microparticle Fillers in Mouse Model.Aesthetic plastic surgery · 2025Article
- Advances in Poly-l-lactic Acid Injections for Facial and Neck Rejuvenation.Plastic and reconstructive surgery. Global open · 2025Article
- Crizotinib: A Novel Strategy to Reverse Immunosuppression in Melanoma by Targeting Lactate Transport.MedComm · 2025Article
- Injectable Methylcellulose/Hyaluronic Acid/Collagen Hydrogel Loaded With Adipose-Derived Stem Cells Alleviates Skin Photoaging via Inhibition of HIF-1α: An in Vitro and in Vivo Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Article
- Evaluating the Efficacy and Safety of Poly-d,l-lactic Acid Administered via Cannula Technique in the Treatment of Moderate Rosacea.Plastic and reconstructive surgery. Global open · 2025Article
- The Efficacy of Combined Microneedling and Topical Poly-d,l-lactic Acid (Juvelook) Application for Facial Pore Reduction and Skin Texture Improvement.Plastic and reconstructive surgery. Global open · 2025Article
- A Comprehensive Analysis of Chemical Composition and Anti-Inflammatory Effects of Cassava Leaf Extracts in Two Varieties inInternational journal of molecular sciences · 2025Article
- Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Angiogenesis promotes rejuvenation in multiple organs, including the skin. Heat shock protein 90 (HSP90), hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) are proangiogenic factors that stimulate the activities of phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and extracellular signal-regulated kinase 1/2 (ERK1/2). Poly-D,L-lactic acid (PDLLA), polynucleotide (PN), and calcium hydroxyapatite (CaHA) are dermal fillers that stimulate the synthesis of dermal collagen. However, it is not yet known whether these compounds promote angiogenesis, which leads to skin rejuvenation. Here, we evaluated whether PDLLA, PN, and CaHA stimulate angiogenesis and skin rejuvenation using H
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.