Evidence map›Paper›PMID 37175655›Full record

ReviewInternational journal of molecular sciences2023

Potassium Channels, Glucose Metabolism and Glycosylation in Cancer Cells.

Agata Wawrzkiewicz-Jałowiecka, Anna Lalik, Agnieszka Lukasiak, Monika Richter-Laskowska, Paulina Trybek, Maciej Ejfler, Maciej Opałka, Sonia Wardejn, Domenico V Delfino

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Agata Wawrzkiewicz-JałowieckaDepartment of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.ORCID 0000-0001-6885-3956
Anna LalikDepartment of Systems Biology and Engineering, Silesian University of Technology, 44-100 Gliwice, Poland.ORCID 0000-0003-4856-9821
Agnieszka LukasiakDepartment of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.
Monika Richter-LaskowskaThe Centre for Biomedical Engineering, Łukasiewicz Research Network-Krakow Institute of Technology, 30-418 Krakow, Poland.ORCID 0000-0002-6591-5944
Paulina TrybekInstitute of Physics, University of Silesia in Katowice, 41-500 Chorzów, Poland.ORCID 0000-0003-4756-9993
Maciej EjflerFaculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, Poland.
Maciej OpałkaFaculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, Poland.
Sonia WardejnFaculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, Poland.
Domenico V DelfinoSection of Pharmacology, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy.ORCID 0000-0003-1792-9468
Silesian University of Technology · PLInstitute of Physics · PLLukasiewicz Research Network - Krakow Institute of Technology · PLUniversity of Perugia · ITWarsaw University of Life Sciences · PL

Funding

Silesian University of Technology 31/010/SDU20/0006-10
6 · The paper itself

Abstract

Potassium channels emerge as one of the crucial groups of proteins that shape the biology of cancer cells. Their involvement in processes like cell growth, migration, or electric signaling, seems obvious. However, the relationship between the function of K+ channels, glucose metabolism, and cancer glycome appears much more intriguing. Among the typical hallmarks of cancer, one can mention the switch to aerobic glycolysis as the most favorable mechanism for glucose metabolism and glycome alterations. This review outlines the interconnections between the expression and activity of potassium channels, carbohydrate metabolism, and altered glycosylation in cancer cells, which have not been broadly discussed in the literature hitherto. Moreover, we propose the potential mediators for the described relations (e.g., enzymes, microRNAs) and the novel promising directions (e.g., glycans-orinented drugs) for further research.

Indexed as

MicroRNAsNeoplasmsGlucoseGlycolysisGlycosylationHumansPotassium ChannelsGlucoseMicroRNAsPotassium Channelscancer biomarkerscancer metabolismchannel glycanesglutaminolysisglycolysisglycosylationmicroRNApotassium channelsTCA cycleWarburg effect

Identifiers

PMID37175655
PMCPMC10178682
OpenAlexW4367317362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.