Evidence map›Paper›PMID 37175651›Full record

ArticleInternational journal of molecular sciences2023

Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat.

Giusi Ianiro, Veronica D'Ezio, Ludovica Carpinelli, Cecilia Casella, Maria Carmela Bonaccorsi di Patti, Luigi Rosa, Piera Valenti, Marco Colasanti, Giovanni Musci, Antimo Cutone and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. ValpalfInternational journal of molecular sciences · 2024
    Article
  11. Article
  12. To Boost or to Reset: The Role of Lactoferrin in Energy Metabolism.International journal of molecular sciences · 2023
    Review
  13. Lactoferrin, the Moonlighting Protein of Innate Immunity.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Giusi IaniroDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-3033-8120
Veronica D'EzioDepartment of Science, University "ROMA TRE", 00146 Rome, Italy.ORCID 0000-0002-5139-2636
Ludovica CarpinelliDepartment of Science, University "ROMA TRE", 00146 Rome, Italy.
Cecilia CasellaDepartment of Science, University "ROMA TRE", 00146 Rome, Italy.ORCID 0009-0004-5311-3786
Maria Carmela Bonaccorsi di PattiDepartment of Biochemical Sciences, Sapienza University of Roma, 00185 Rome, Italy.ORCID 0000-0002-4794-7037
Luigi RosaDepartment of Public Health and Infectious Diseases, Sapienza University of Roma, 00185 Rome, Italy.ORCID 0000-0002-1252-6080
Piera ValentiDepartment of Public Health and Infectious Diseases, Sapienza University of Roma, 00185 Rome, Italy.
Marco ColasantiDepartment of Science, University "ROMA TRE", 00146 Rome, Italy.ORCID 0000-0002-5752-4943
Giovanni MusciDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-5196-709X
Antimo CutoneDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-7492-8616
Tiziana PersichiniDepartment of Science, University "ROMA TRE", 00146 Rome, Italy.
Roma Tre University · ITUniversity of Molise · ITSapienza University of Rome · IT

Funding

MUR ARTICOLO 1, COMMI 314-337 LEGGE 232/2016
6 · The paper itself

Abstract

The Trans-Activator of Transcription (Tat) of Human Immunodeficiency Virus (HIV-1) is involved in virus replication and infection and can promote oxidative stress in human astroglial cells. In response, host cells activate transcription of antioxidant genes, including a subunit of System X

Indexed as

HIV-1NeuroblastomaAntioxidantsGlutamatesHumansIronLactoferrinOxidative StressAntioxidantsGlutamatesIronLactoferrinastrocytesHIV-1 Tatiron saturationLactoferrinneurotoxicityNrf-2oxidative stressSystem Xc−

Identifiers

PMID37175651
PMCPMC10178013
OpenAlexW4367317379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.