Evidence map›Paper›PMID 37175649›Full record

ArticleInternational journal of molecular sciences2023

Leveraging the 3-Chloro-4-fluorophenyl Motif to Identify Inhibitors of Tyrosinase from

Salvatore Mirabile, Laura Ielo, Lisa Lombardo, Federico Ricci, Rosaria Gitto, Maria Paola Germanò, Vittorio Pace, Laura De Luca

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Chemical Profile and Health-Promoting Activities ofPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Salvatore MirabileDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.
Laura IeloDepartment of Chemistry, University of Turin, Via P. Giuria 7, 10125 Torino, Italy.ORCID 0000-0001-9976-0170
Lisa LombardoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.
Federico RicciDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.
Rosaria GittoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.
Maria Paola GermanòDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.
Vittorio PaceDepartment of Chemistry, University of Turin, Via P. Giuria 7, 10125 Torino, Italy.ORCID 0000-0003-3037-5930
Laura De LucaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy.ORCID 0000-0003-0614-5713
University of Messina · ITUniversity of Turin · IT

Funding

Ministry of Education, Universities and Research Finanziamento delle Attività Base di Ricerca" FFABR UNIME
6 · The paper itself

Abstract

Tyrosinase (EC 1.14.18.1) is implicated in melanin production in various organisms. There is a growing body of evidence suggesting that the overproduction of melanin might be related to several skin pigmentation disorders as well as neurodegenerative processes in Parkinson's disease. Based on this consideration, the development of tyrosinase inhibitors represents a new challenge to identify new agents in pharmaceutical and cosmetic applications. With the goal of identifying tyrosinase inhibitors from a synthetic source, we employed a cheap and facile preliminary assay using tyrosinase from

Indexed as

AgaricusMonophenol MonooxygenaseCatalytic DomainEnzyme InhibitorsMelaninsMolecular Docking SimulationEnzyme InhibitorsMelaninsMonophenol Monooxygenase3-chloro-4-fluorophenyl moietyAgaricus bisporusmolecular modellingTyrosinase

Identifiers

PMID37175649
PMCPMC10177926
OpenAlexW4367300091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.