Evidence map›Paper›PMID 37175566›Full record

SynthesisInternational journal of molecular sciences2023

Comprehensive Analysis of the Prognostic Value of Circulating MMP-7 Levels in Urothelial Carcinoma: A Combined Cohort Analysis, Systematic Review, and Meta-Analysis.

András Kubik, Isabel Pinto Amorim das Virgens, Anett Szabó, Melinda Váradi, Anita Csizmarik, Attila Keszthelyi, Attila Majoros, Péter Fehérvári, Péter Hegyi, Nándor Ács and 2 more

Open access · goldAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Enzymes Dysregulation in Cancer: From Diagnosis to Therapeutical Approaches.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

András KubikDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.ORCID 0000-0001-6901-9701
Isabel Pinto Amorim das VirgensCenter for Translational Medicine, Semmelweis University, 1082 Budapest, Hungary.
Anett SzabóDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.ORCID 0000-0002-1081-2462
Melinda VáradiDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.
Anita CsizmarikDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.
Attila KeszthelyiDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.
Attila MajorosDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.
Péter FehérváriCenter for Translational Medicine, Semmelweis University, 1082 Budapest, Hungary.
Péter HegyiCenter for Translational Medicine, Semmelweis University, 1082 Budapest, Hungary.
Nándor ÁcsCenter for Translational Medicine, Semmelweis University, 1082 Budapest, Hungary.ORCID 0000-0002-1919-1869
Péter NyirádyDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.
Tibor SzarvasDepartment of Urology, Semmelweis University, 1082 Budapest, Hungary.
Semmelweis University · HU

Funding

János Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00451/20/5National Research Development and Innovation Fund K139059New National Excellence Program ÚNKP-21-3-II-SE-13New National Excellence Program ÚNKP-21-5-SE-3
6 · The paper itself

Abstract

Lymph node (LN) status is the most significant prognostic factor for invasive urothelial bladder cancer (UBC); however, the optimal extent of LN dissection (LND) is debated. We assessed circulating matrix metalloproteinase-7 (MMP-7) as a prognostic factor and decision-making marker for the extent of LND. Preoperative serum MMP-7 levels were determined in two independent UBC cohorts (n = 188; n = 68) and in one control cohort (n = 97) by using the ELISA method. A systematic review and meta-analysis on the prognostic role of circulating pretreatment MMP-7 levels were performed. Serum MMP-7 levels were higher in patients compared to controls (

Indexed as

Carcinoma, Transitional CellUrinary Bladder NeoplasmsCohort StudiesCystectomyHumansLymph NodesMatrix Metalloproteinase 7PrognosisMatrix Metalloproteinase 7biomarkerlymphadenectomymatrilysinmicrometastasesMMP-7overall survivalprognosticationradical cystectomyurinary bladder cancerurothelial cancer

Identifiers

PMID37175566
PMCPMC10178327
OpenAlexW4367054663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.