Evidence map›Paper›PMID 37175499›Full record

ArticleInternational journal of molecular sciences2023

Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer Cells.

Noura Al-Zeheimi, Yan Gao, Peter A Greer, Sirin A Adham

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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  5. Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Noura Al-ZeheimiDepartment of Biology, College of Science, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0003-2905-2288
Yan GaoDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Peter A GreerDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Sirin A AdhamDepartment of Biology, College of Science, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0002-8349-6202
Queen's University · CASultan Qaboos University · OM

Funding

the Research Council of Oman (TRC), Sultan Qaboos University, and the Canadian Institutes of Health Research ORG/HSS/14/006. (TRC#137), IG/SCI/BIOL/18/03, and PJT-156221 to P.A.G
6 · The paper itself

Abstract

Breast cancer (BC) metastasis remains a leading cause of female mortality. Neuropilin-1 (NRP-1) is a glycoprotein receptor that plays ligand-dependent roles in BC. Clinical studies indicate its correlation with metastatic disease; however, its functional role in BC metastasis remains uncertain. CRISPR-Cas9 was used to knockout the

Indexed as

NeoplasmsSignal TransductionAnimalsFemaleHumansMDA-MB-231 CellsMiceNeuropilin-1Neuropilin-2Neuropilin-1Neuropilin-2NRP1 protein, humanbreast cancerCRISPRknockoutmetastasisneuropilin-1transcriptome

Identifiers

PMID37175499
PMCPMC10178772
OpenAlexW4366988868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.