Evidence map›Paper›PMID 37175477›Full record

ArticleInternational journal of molecular sciences2023

Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma.

Marika A Franczak, Oliwia Krol, Gabriela Harasim, Agata Jedrzejewska, Nadia Zaffaroni, Carlotta Granchi, Filippo Minutolo, Amir Avan, Elisa Giovannetti, Ryszard T Smolenski and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  14. Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Marika A FranczakDepartment of Biochemistry, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-9525-4374
Oliwia KrolDepartment of Biochemistry, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0001-5599-0417
Gabriela HarasimDepartment of Biochemistry, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-6774-7438
Agata JedrzejewskaDepartment of Biochemistry, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-8219-7497
Nadia ZaffaroniMolecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.ORCID 0000-0002-4669-0890
Carlotta GranchiDipartimento di Farmacia, Università di Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5849-0722
Filippo MinutoloDipartimento di Farmacia, Università di Pisa, 56126 Pisa, Italy.ORCID 0000-0002-3312-104X
Amir AvanDepartment of Medical Oncology, Amsterdam University Medical Centers, Location VUmc, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-4968-0962
Elisa GiovannettiDepartment of Medical Oncology, Amsterdam University Medical Centers, Location VUmc, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-7565-7504
Ryszard T SmolenskiDepartment of Biochemistry, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-0190-9414
Godefridus J PetersDepartment of Biochemistry, Medical University of Gdansk, 80-210 Gdańsk, Poland.ORCID 0000-0002-5447-2877
Gdańsk Medical University · PLAmsterdam University Medical Centers · NLUniversity of Pisa · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITFondazione Pisa · ITMashhad University of Medical Sciences · IR

Funding

Italian Association for Cancer Research IG-grant 24444Law Offices of Peter G. Angelos Grant' from the Mesothelioma Applied Research Foundation MARTNational Science Center 2018/31/B/NZ7/02909
6 · The paper itself

Abstract

Malignant mesothelioma (MM) is a highly aggressive and resistant tumor. The prognostic role of key effectors of glycolytic metabolism in MM prompted our studies on the cytotoxicity of new inhibitors of glucose transporter type 1 (GLUT-1) and lactate dehydrogenase-A (LDH-A) in relation to ATP/NAD

Indexed as

MesotheliomaMesothelioma, MalignantAdenosine TriphosphateCell Line, TumorGlucoseGlucose Transport Proteins, FacilitativeGlycolysisHumansLactate Dehydrogenase 5NADAdenosine TriphosphateGlucoseGlucose Transport Proteins, FacilitativeLactate Dehydrogenase 5NADanticancer treatmentcancer metabolismchemoresistanceglucose transporter type 1lactate dehydrogenasemalignant mesothelioma

Identifiers

PMID37175477
PMCPMC10177874
OpenAlexW4366989036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.