Evidence map›Paper›PMID 37175453›Full record

ReviewInternational journal of molecular sciences2023

Cancer Stem Cells and Prostate Cancer: A Narrative Review.

Yazan Al Salhi, Manfredi Bruno Sequi, Fabio Maria Valenzi, Andrea Fuschi, Alessia Martoccia, Paolo Pietro Suraci, Antonio Carbone, Giorgia Tema, Riccardo Lombardo, Antonio Cicione and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. METTL3/YTHDF1-Driven SURF6 Promotes Prostate Cancer Stemness via CDK4.Journal of cellular and molecular medicine · 2026
    Article
  4. Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yazan Al SalhiUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Manfredi Bruno SequiUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Fabio Maria ValenziUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Andrea FuschiUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Alessia MartocciaUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Paolo Pietro SuraciUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.
Antonio CarboneUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0003-1725-1933
Giorgia TemaUrology Unit, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Riccardo LombardoUrology Unit, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0003-2890-3159
Antonio CicioneUrology Unit, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Antonio Luigi PastoreUrology Unit, Department of Medico-Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0003-4293-9174
Cosimo De NunzioUrology Unit, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-2190-512X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells with the remarkable ability to initiate, propagate, and spread malignant disease. In the past years, several authors have focused on the possible role of CSCs in PCa development and progression. PCa CSCs typically originate from a luminal prostate cell. Three main pathways are involved in the CSC development, including the Wnt, Sonic Hedgehog, and Notch signaling pathways. Studies have observed an important role for epithelial mesenchymal transition in this process as well as for some specific miRNA. These studies led to the development of studies targeting these specific pathways to improve the management of PCa development and progression. CSCs in prostate cancer represent an actual and promising field of research.

Indexed as

MicroRNAsProstatic NeoplasmsHedgehog ProteinsHumansMaleNeoplastic Stem CellsSignal TransductionHedgehog ProteinsMicroRNAsepigeneticmicroRNAprostate cancerstem cells

Identifiers

PMID37175453
PMCPMC10178135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.