Microstructure, Physical and Biological Properties, and BSA Binding Investigation of Electrospun Nanofibers Made of Poly(AA-co-ACMO) Copolymer and Polyurethane.

Hanaa Mansour, Samia M Elsigeny, Fawzia I Elshami, Mohamed Auf, Shaban Y Shaban, Rudi van Eldik

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.7field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Hanaa MansourChemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

Samia M ElsigenyChemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

Fawzia I ElshamiChemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

Mohamed AufChemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

Shaban Y ShabanChemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0003-3717-6803

Rudi van EldikDepartment of Chemistry and Pharmacy, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.ORCID 0000-0003-4271-0118

Kafrelsheikh University · EGFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, poly(AA-co-ACMO) and polyurethane-based nanofibers were prepared in a ratio of 1:1 (NF11) and 2:1 (NF21) as antimicrobial carriers for chronic wound management. Different techniques were used to characterize the nanofibers, and poly(AA-co-ACMO) was mostly found on the surface of PU. With an increase in poly(AA-co-ACMO) dose from 0 (PU) and 1:1 (NF11) to 2:1 (NF21) in the casting solution, the contact angle (CA) was reduced from 137 and 95 to 24, respectively, and hydrophilicity was significantly increased. As most medications inhibit biological processes by binding to a specific protein, in vitro protein binding was investigated mechanistically using a stopped-flow technique. Both NF11 and NF21 bind to BSA via two reversible steps: a fast second-order binding followed by a slow first-order one. The overall parameters for NF11 (

Indexed as

NanofibersPolyurethanesAnti-Bacterial AgentsHydrophobic and Hydrophilic InteractionsPolymersAnti-Bacterial AgentsPolymersPolyurethanesantibacterialBSA-affinityelectrospunhydrophilicnanofiberpoly(acrylic acid-co-acryloylmorpholine)wound healing

Identifiers

PMID37175361

DOI10.3390/molecules28093951

PMCPMC10180346

OpenAlexW4376630920

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.