Evidence map›Paper›PMID 37175271›Full record

ArticleMolecules (Basel, Switzerland)2023

Elagolix Sodium Salt and Its Synthetic Intermediates: A Spectroscopic, Crystallographic, and Conformational Study.

Samuele Ciceri, Diego Colombo, Enrico M A Fassi, Patrizia Ferraboschi, Giovanni Grazioso, Paride Grisenti, Marco Iannone, Carlo Castellano, Fiorella Meneghetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuele CiceriDepartment of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0003-1202-941X
Diego ColomboDepartment of Medical Biotechnology and Translational Medicine, University of Milan, Via C. Saldini 50, 20133 Milano, Italy.ORCID 0000-0003-1436-2304
Enrico M A FassiDepartment of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0001-6282-4273
Patrizia FerraboschiDepartment of Medical Biotechnology and Translational Medicine, University of Milan, Via C. Saldini 50, 20133 Milano, Italy.ORCID 0000-0002-2349-8126
Giovanni GraziosoDepartment of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0002-3261-9356
Paride GrisentiChemical-Pharmaceutical Consulting and IP Management, Viale G. da Cermenate 58, 20141 Milano, Italy.
Marco IannoneTecnomed Foundation, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy.ORCID 0000-0002-1170-5570
Carlo CastellanoDepartment of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.ORCID 0000-0002-7497-0670
Fiorella MeneghettiDepartment of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy.ORCID 0000-0002-6511-7360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elagolix sodium salt is the first marketed orally active non-peptide gonadotropin-releasing hormone receptor antagonist (GnRHR-ant) for the management of hormone dependent diseases, such as endometriosis and uterine fibroids. Despite its presence on the market since 2018, a thorough NMR analysis of this drug, together with its synthetic intermediates, is still lacking. Hence, with the aim of filling this literature gap, we here performed a detailed NMR investigation, which allowed the complete assignment of the

Indexed as

EndometriosisGonadotropin-Releasing HormoneFatty AlcoholsFemaleHumansHydrocarbons, FluorinatedPyrimidinesSodium ChlorideSodium Chloride, DietaryelagolixFatty AlcoholsGonadotropin-Releasing HormoneHydrocarbons, FluorinatedPyrimidinesSodium ChlorideSodium Chloride, Dietaryatropisomerismconformational analysiscrystal structureendometriosisGnRHR antagonistNMR spectroscopyuterine fibroids

Identifiers

PMID37175271
PMCPMC10180344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.