Evidence map›Paper›PMID 37175205›Full record

ArticleMolecules (Basel, Switzerland)2023

Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells.

Ya-Fang Liao, Hui-Jun Pan, Nuerziba Abudurezeke, Chun-Lu Yuan, Yan-Li Yuan, Shu-Da Zhao, Dan-Dan Zhang, Shuang Huang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ya-Fang LiaoInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.ORCID 0000-0003-3470-1617
Hui-Jun PanShanghai Skin Disease Hospital, Shanghai 200443, China.ORCID 0009-0004-1083-6335
Nuerziba AbudurezekeInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.ORCID 0009-0000-6467-431X
Chun-Lu YuanInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.ORCID 0000-0003-1911-1408
Yan-Li YuanInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.ORCID 0009-0000-0824-768X
Shu-Da ZhaoInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.ORCID 0009-0001-7967-1629
Dan-Dan ZhangInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.ORCID 0000-0003-0591-2167
Shuang HuangDepartment of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Shanghai University of Traditional Chinese Medicine · CNShanghai Skin Disease Hospital · CNUniversity of Florida · US

Funding

Innovation Project for Undergraduates of Shanghai University of Traditional Chinese Medicine 202210268239National Natural Science Foundation of China 81773946, 81573673, 81001666
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive brain tumor, with high mortality. Timosaponin AIII (TIA), a steroidal saponin isolated from the medicinal plant

Indexed as

beta CateninGlioblastomaApoptosisCyclic GMPHumansSignal TransductionSteroidsbeta CateninCyclic GMPSteroidscGMP pathwayglioblastomaPDE5timosaponin AIIIβ-catenin pathway

Identifiers

PMID37175205
PMCPMC10180307
OpenAlexW4367298042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.