Evidence map›Paper›PMID 37175202›Full record

ArticleMolecules (Basel, Switzerland)2023

Ketonization of Ginsenoside C-K by Novel Recombinant 3-β-Hydroxysteroid Dehydrogenases and Effect on Human Fibroblast Cells.

Yan Jin, Dandan Wang, Wan-Taek Im, Muhammad Zubair Siddiqi, Deok-Chun Yang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Discovery of an SQS-PSY Domain-Containing Protein inInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Yan JinSchool of Life Science, Nantong University, Nantong 226019, China.
Dandan WangCollege of Life Sciences, Yantai University, Yantai 264005, China.
Wan-Taek ImDepartment of Biotechnology, Hankyong National University, 327 Jungang-ro, Anseong-si 17579, Gyeonggi-do, Republic of Korea.
Muhammad Zubair SiddiqiDepartment of Biotechnology, Hankyong National University, 327 Jungang-ro, Anseong-si 17579, Gyeonggi-do, Republic of Korea.
Deok-Chun YangDepartment of Oriental Medicinal Material & Processing, College of Life Science, Kyung Hee University, Seocheon-dong, Giheung-gu, Yongin-si 17104, Gyeonggi-do, Republic of Korea.ORCID 0000-0003-2394-4728
Hankyong National University · KRKyung Hee University · KRNantong University · CNYantai University · CN

Funding

Brain Pool Program through the National Research Foundation of Korea (NRF) funded by the Min- istry of Science and ICT ( Project No. 2019H1D3A1A02070958Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry(IPET) through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Af- fairs (MAFRA) (321038-5)Large Instruments Open Foundation of Nantong University KFJN2231Nantong Science and Technology Foundation of China JC202105
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe ginsenoside compound K (C-K) (which is a de-glycosylated derivative of major ginsenosides) is effective in the treatment of cancer, diabetes, inflammation, allergy, angiogenesis, aging, and has neuroprotective, and hepatoprotective than other minor ginsenosides. Thus, a lot of studies have been focused on the conversion of major ginsenosides to minor ginsenosides using glycoside hydrolases but there is no study yet published for the bioconversion of minor ginsenosides into another high pharmacological active compound. Therefore, the objective of this study to identify a new gene (besides the glycoside hydrolases) for the conversion of minor ginsenosides C-K into another highly pharmacological active compound. METHODS AND

results

Indexed as

Ginsenosides3-Hydroxysteroid Dehydrogenasesbeta-GlucosidaseBiotransformationCollagen Type IFibroblastsGlycoside HydrolasesHumans3-Hydroxysteroid Dehydrogenasesbeta-GlucosidaseCollagen Type Iginsenoside compound KGinsenosidesGlycoside HydrolasesProcollagen Type I3-oxo-C-K3-β-hydroxysteroid dehydrogenaseginsenoside C-KketonizationLactobacillus brevis DCY65-1

Identifiers

PMID37175202
PMCPMC10180105
OpenAlexW4367319685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.