Evidence map›Paper›PMID 37175067›Full record

ArticleMolecules (Basel, Switzerland)2023

A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene.

Nicolai A Aksenov, Nikolai A Arutiunov, Igor A Kurenkov, Vladimir V Malyuga, Dmitrii A Aksenov, Daria S Momotova, Anna M Zatsepilina, Elizaveta A Chukanova, Alexander V Leontiev, Alexander V Aksenov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicolai A AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-7125-9066
Nikolai A ArutiunovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0003-2675-9093
Igor A KurenkovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-0911-4093
Vladimir V MalyugaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.
Dmitrii A AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-0727-9652
Daria S MomotovaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.
Anna M ZatsepilinaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.
Elizaveta A ChukanovaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.
Alexander V LeontievDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0003-4742-1999
Alexander V AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia.ORCID 0000-0002-6644-9949
North-Caucasus Federal University · RU

Funding

Russian Science Foundation 21-73-20051
6 · The paper itself

Abstract

A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4'-phenyl-4'H-spiro[indole-3,5'-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.

Indexed as

C3-amination of indolescascade transformationsphenylacetonitrile extrusion

Identifiers

PMID37175067
PMCPMC10180116
OpenAlexW4366975254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.