Evidence map›Paper›PMID 37174742›Full record

ReviewCells2023

Retinal Cell Damage in Diabetic Retinopathy.

Jing Zhou, Bo Chen

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  20. Neuroprotection in Diabetes Retinal Disease: An Unmet Medical Need.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jing ZhouDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bo ChenDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-2768-9007
Icahn School of Medicine at Mount Sinai · US

Funding

CaMKII-mediated Neuroprotection of Retinal Ganglion CellsR01EY028921 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHEN, BO · 2019 to 2022
$2.4M
Regeneration of rod photoreceptors from Muller glial cells in adult mouse retinaR01EY024986 · NEI · YALE UNIVERSITY · PI CHEN, BO · 2016 to 2019
$1.6M
NEI NIH HHS R01 EY024986NEI NIH HHS R01 EY028921
6 · The paper itself

Abstract

Diabetic retinopathy (DR), the most common microvascular complication that occurs in diabetes mellitus (DM), is the leading cause of vision loss in working-age adults. The prevalence of diabetic retinopathy is approximately 30% of the diabetic population and untreated DR can eventually cause blindness. For decades, diabetic retinopathy was considered a microvascular complication and clinically staged by its vascular manifestations. In recent years, emerging evidence has shown that diabetic retinopathy causes early neuronal dysfunction and neurodegeneration that may precede vascular pathology and affect retinal neurons as well as glial cells. This knowledge leads to new therapeutic strategies aiming to prevent dysfunction of retinal neurons at the early stage of DR. Early detection and timely treatment to protect retinal neurons are critical to preventing visual loss in DR. This review provides an overview of DR and the structural and functional changes associated with DR, and discusses neuronal degeneration during diabetic retinopathy, the mechanisms underlying retinal neurodegeneration and microvascular complications, and perspectives on current and future clinic therapies.

Indexed as

Diabetes MellitusDiabetic RetinopathyRetinal NeuronsHumansNeurogliaRetinaVision Disordersclinic therapydiabetes mellitusdiabetic retinopathymicrovascular complicationneurodegenerationneuronal dysfunction

Identifiers

PMID37174742
PMCPMC10177610
OpenAlexW4375862400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.