Evidence map›Paper›PMID 37174549›Full record

ArticleAnimals : an open access journal from MDPI2023

Development and Application of a Physiologically Based Pharmacokinetic Model for Diclazuril in Broiler Chickens.

Fang Yang, Mei Zhang, Yang-Guang Jin, Jun-Cheng Chen, Ming-Hui Duan, Yue Liu, Ze-En Li, Xing-Ping Li, Fan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fang YangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Mei ZhangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Yang-Guang JinCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Jun-Cheng ChenCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Ming-Hui DuanCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Yue LiuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Ze-En LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Xing-Ping LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.ORCID 0000-0001-6352-4627
Fan YangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.ORCID 0000-0001-8847-1031

Funding

Foundation for the University Young Key Teacher Program of Henan Province 2021GGJS044
6 · The paper itself

Abstract

Withdrawal periods for diclazuril in broilers have traditionally been determined through regression analysis. However, over the last two decades, the physiologically based pharmacokinetic (PBPK) model has gained prominence as a predictive tool for veterinary drug residues, which offers an alternative method for establishing appropriate withdrawal periods for veterinary drugs. In this current study, a flow-limited PBPK model was developed to predict diclazuril concentrations in broilers following long-duration administration via medicated feed and water. This model consists of nine compartments, including arterial and venous plasma, lung, muscle, skin + fat, kidney, liver, intestine contents, and the rest of the body compartment. Physiological parameters such as tissue weights (V

Indexed as

broiler chickensdiclazurilphysiologically based pharmacokinetic (PBPK) modelresidue predictionwithdrawal interval

Identifiers

PMID37174549
PMCPMC10177140

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.