Evidence map›Paper›PMID 37174089›Full record

ReviewCancers2023

Potential Immunotherapy Targets for Liver-Directed Therapies, and the Current Scope of Immunotherapeutics for Liver-Related Malignancies.

Jonathan Charles, Andrea Vrionis, Arian Mansur, Trevor Mathias, Jamil Shaikh, Aaron Ciner, Yixing Jiang, Nariman Nezami

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Current Research in Drug-Free Cancer Therapies.Bioengineering (Basel, Switzerland) · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jonathan CharlesMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USA.ORCID 0000-0002-2868-6687
Andrea VrionisMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USA.ORCID 0009-0000-0305-5291
Arian MansurHarvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0003-2406-5127
Trevor MathiasSchool of Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0002-2830-8475
Jamil ShaikhMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USA.ORCID 0000-0003-0752-5283
Aaron CinerDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yixing JiangDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Nariman NezamiDivision of Vascular and Interventional Radiology, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USUniversity of South Florida · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, is increasing in incidence and mortality across the globe. An improved understanding of the complex tumor microenvironment has opened many therapeutic doors and led to the development of novel pharmaceuticals targeting cellular signaling pathways or immune checkpoints. These interventions have significantly improved tumor control rates and patient outcomes, both in clinical trials and in real-world practice. Interventional radiologists play an important role in the multidisciplinary team given their expertise in minimally invasive locoregional therapy, as the bulk of these tumors are usually in the liver. The aim of this review is to highlight the immunological therapeutic targets for primary liver cancers, the available immune-based approaches, and the contributions that interventional radiology can provide in the care of these patients.

Indexed as

hepatocellular carcinomaimmunotherapyinterventional oncologyinterventional radiologyintrahepatic cholangiocarcinoma

Identifiers

PMID37174089
PMCPMC10177356
OpenAlexW4376630385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.