Evidence map›Paper›PMID 37173969›Full record

ArticleCancers2023

Risk Estimation in Non-Enhancing Glioma: Introducing a Clinical Score.

Philip Dao Trong, Samuel Kilian, Jessica Jesser, David Reuss, Fuat Kaan Aras, Andreas Von Deimling, Christel Herold-Mende, Andreas Unterberg, Christine Jungk

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Philip Dao TrongDepartment of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-8063-5425
Samuel KilianInstitute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.
Jessica JesserDepartment of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-1236-8828
David ReussDivision of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Fuat Kaan ArasDivision of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Andreas Von DeimlingDivision of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-5863-540X
Christel Herold-MendeDepartment of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-1915-745X
Andreas UnterbergDepartment of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0003-3742-3288
Christine JungkDepartment of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The preoperative grading of non-enhancing glioma (NEG) remains challenging. Herein, we analyzed clinical and magnetic resonance imaging (MRI) features to predict malignancy in NEG according to the 2021 WHO classification and developed a clinical score, facilitating risk estimation. A discovery cohort (2012-2017, n = 72) was analyzed for MRI and clinical features (T2/FLAIR mismatch sign, subventricular zone (SVZ) involvement, tumor volume, growth rate, age, Pignatti score, and symptoms). Despite a "low-grade" appearance on MRI, 81% of patients were classified as WHO grade 3 or 4. Malignancy was then stratified by: (1) WHO grade (WHO grade 2 vs. WHO grade 3 + 4) and (2) molecular criteria (IDH

Indexed as

CDKN2A/BIDH mutationlower-grade gliomamalignant gliomamolecular classificationnon-enhancing gliomaprognostic scorerisk estimation

Identifiers

PMID37173969
PMCPMC10177456
OpenAlexW4367182314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.