Evidence map›Paper›PMID 37173947›Full record

ArticleCancers2023

Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma.

Claudia Wing-Kwan Wu, Rashid Nok-Shun Lui, Vincent Wai-Sun Wong, Tsz-Fai Yam, Terry Cheuk-Fung Yip, Ken Liu, Jimmy Che-To Lai, Yee-Kit Tse, Tony Shu-Kam Mok, Henry Lik-Yuen Chan and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Claudia Wing-Kwan WuMedical Data Analytics Centre, Hong Kong SAR, China.ORCID 0000-0003-1401-0173
Rashid Nok-Shun LuiMedical Data Analytics Centre, Hong Kong SAR, China.ORCID 0000-0003-1277-9595
Vincent Wai-Sun WongMedical Data Analytics Centre, Hong Kong SAR, China.
Tsz-Fai YamMedical Data Analytics Centre, Hong Kong SAR, China.
Terry Cheuk-Fung YipMedical Data Analytics Centre, Hong Kong SAR, China.
Ken LiuAW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.ORCID 0000-0002-0453-3168
Jimmy Che-To LaiMedical Data Analytics Centre, Hong Kong SAR, China.ORCID 0000-0002-5749-1598
Yee-Kit TseMedical Data Analytics Centre, Hong Kong SAR, China.
Tony Shu-Kam MokState Key Laboratory of Translational Oncology, Department of Clinical Oncology, The Hong Kong Cancer Institute, Hong Kong SAR, China.
Henry Lik-Yuen ChanMedical Data Analytics Centre, Hong Kong SAR, China.ORCID 0000-0002-7790-1611
Kelvin Kwok-Chai NgDepartment of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-3679-6368
Grace Lai-Hung WongMedical Data Analytics Centre, Hong Kong SAR, China.ORCID 0000-0002-2863-9389
Stephen Lam ChanState Key Laboratory of Translational Oncology, Department of Clinical Oncology, The Hong Kong Cancer Institute, Hong Kong SAR, China.ORCID 0000-0001-8998-5480
Prince of Wales Hospital · CNChinese University of Hong Kong · HKRoyal Prince Alfred Hospital · AUUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Baveno VII criteria are used in patients with liver cirrhosis to predict high-risk varices in patients with liver cirrhosis. Yet its use in patients with advanced hepatocellular carcinoma (HCC) has not been validated. HCC alone is accompanied with a higher variceal bleeding risk due to its association with liver cirrhosis and portal vein thrombosis. The use of systemic therapy in advanced HCC has been thought to further augment this risk. Upper endoscopy is commonly used to evaluate for the presence of varices before initiation of treatment with systemic therapy. Yet it is associated with procedural risks, waiting time and limited availability in some localities which may delay the commencement of systemic therapy. Our study successfully validated the Baveno VI criteria with a 3.5% varices needing treatment (VNT) missed rate, also with acceptable <5% VNT missed rates when considering alternative liver stiffness (LSM) and platelet cut-offs. The Baveno VII clinically significant portal hypertension rule-out criteria (LSM < 15 kPa and platelet >150 × 10

Indexed as

Baveno criteriahepatocellular carcinomahigh risk varicesliver stiffness measurementplateletsystemic therapies

Identifiers

PMID37173947
PMCPMC10177352
OpenAlexW4367051763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.