Evidence map›Paper›PMID 37173903›Full record

ArticleCancers2023

Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328.

Helena Järemo, Julius Semenas, Sofia Halin Bergström, Marie Lundholm, Elin Thysell, Anders Widmark, Sead Crnalic, Erik Bovinder Ylitalo, Anders Bergh, Maria Brattsand and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Helena JäremoDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.ORCID 0009-0002-0666-8952
Julius SemenasDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-5394-7239
Sofia Halin BergströmDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.
Marie LundholmDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0003-4319-8224
Elin ThysellDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.
Anders WidmarkDepartment of Radiation Sciences, Oncology, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-9845-055X
Sead CrnalicDepartment of Surgical and Perioperative Sciences, Orthopedics, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-5875-4946
Erik Bovinder YlitaloDepartment of Radiation Sciences, Oncology, Umeå University, 901 87 Umeå, Sweden.
Anders BerghDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-5163-5821
Maria BrattsandDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-7175-1336
Pernilla WikströmDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0002-6347-1999
Umeå University · SE

Funding

Cancer Research Foundation in Northern Sweden AMP 21-1061Prostatacancerförbundet Wikström 2022Swedish Cancer Society 21-1856Swedish Foundation for Strategic Research RB13-0119Swedish Research Council 2022-00946
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are aberrantly expressed in prostate cancer (PC), but comprehensive knowledge about their levels and function in metastatic PC is lacking. Here, we explored the differential expression of miRNA profiles during PC progression to bone metastasis, and further focused on the downregulation of miRNA-23c and -4328 and their impact on PC growth in experimental models. Using microarray screening, the levels of 1510 miRNAs were compared between bone metastases (

Indexed as

blood vesselsbone metastasisextracellular vesiclesmicroarraymicroRNA-23cmicroRNA-4328proliferationprostate cancerproteomics

Identifiers

PMID37173903
PMCPMC10177411
OpenAlexW4366834102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.