Evidence map›Paper›PMID 37173564›Full record

ReviewCanadian journal of anaesthesia = Journal canadien d'anesthesie2023

Black representation in critical care randomized controlled trials: a meta-epidemiological study.

Cheikh Tchouambou Youmbi, Tyler Jordan Gilman, Ines Carole Ndzana Siani, Ida-Ehosa Olaye, Anuoluwa Faith Popoola, Sammah Abdulmalik Yahya, Kwadwo Kyeremanteng, Sheetal Gandotra, Jonathan Dale Casey, Matthew Wall Semler and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cheikh Tchouambou YoumbiMcMaster Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-4384-6941
Tyler Jordan GilmanMcMaster Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Ines Carole Ndzana SianiDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Ida-Ehosa OlayeDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Anuoluwa Faith PopoolaMcMaster Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Sammah Abdulmalik YahyaMcMaster Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Kwadwo KyeremantengFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Sheetal GandotraDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama Birmingham, Birmingham, AL, USA.
Jonathan Dale CaseyDepartment of Medicine, Vanderbilt University, Nashville, TN, USA.
Matthew Wall SemlerDepartment of Medicine, Vanderbilt University, Nashville, TN, USA.
Lawrence MbuagbawDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Abubaker KhalifaDepartment of Medicine (Critical Care), Juravinski Hospital, McMaster University, Hamilton, ON, Canada.
Bram RochwergDepartment of Medicine (Critical Care), Juravinski Hospital, McMaster University, Hamilton, ON, Canada. rochwerg@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe under-representation of Black people within critical care research limits the generalizability of randomized controlled trials (RCTs). This meta-epidemiologic study investigated the proportionate representation of Black people enrolled at USA and Canadian study sites from high impact critical care RCTs. SOURCE: We searched for critical care RCTs published in general medicine and intensive care unit (ICU) journals between 1 January 2016 and 31 December 2020. We included RCTs that enrolled critically ill adults at USA or Canadian sites and provided race-based demographic data by study site. We compared study-based racial demographics with site-level city-based demographics and pooled representation of Black people across studies, cities, and centres using a random effects model. We used meta-regression to explore the impact of the following variables on Black representation in critical care RCTs: country, drug intervention, consent model, number of centres, funding, study site city, and year of publication. PRINCIPAL

findingsWe included 21 eligible RCTs. Of these, 17 enrolled at only USA sites, two at only Canadian sites, and two at both USA and Canadian sites. Black people were under-represented in critical care RCTs by 6% compared with population-based city demographics (95% confidence interval, 1 to 11). Using meta-regression, after controlling for pertinent variables, the country of the study site was the only significant source of heterogeneity (P = 0.02).

conclusionBlack people are under-represented in critical care RCTs compared with site-level city-based demographics. Interventions are required to ensure adequate Black representation in critical care RCTs at both USA and Canadian study sites. Further research is needed to investigate the factors contributing to Black under-representation in critical care RCTs.

Indexed as

Critical CarePatient SelectionRandomized Controlled Trials as TopicAdultBlack or African AmericanBlack PeopleCanadaHumansUnited Statescritical carerandomized controlled trialsrepresentation

Identifiers

PMID37173564
PMCPMC10180607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.