Evidence map›Paper›PMID 37173315›Full record

ArticleNature communications2023

Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice.

Samuel A Druzak, Matteo Tardelli, Suzanne G Mays, Mireille El Bejjani, Xulie Mo, Kristal M Maner-Smith, Thomas Bowen, Michael L Cato, Matthew C Tillman, Akiko Sugiyama and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Samuel A Druzak *Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Matteo Tardelli *Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Suzanne G MaysDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Mireille El BejjaniDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.ORCID 0000-0001-7696-2175
Xulie MoDepartment of Chemical Biology and Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Kristal M Maner-SmithEmory Integrated Lipidomics and Metabolomics Core, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Thomas BowenEmory Integrated Lipidomics and Metabolomics Core, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Michael L CatoDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Matthew C TillmanDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.
Akiko SugiyamaJoan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-3620-2160
Yang XieJoan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-2190-6966
Haian FuDepartment of Chemical Biology and Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA.ORCID 0000-0002-2362-7979
David E CohenJoan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Eric A OrtlundDepartment of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, USA. eortlun@emory.edu.ORCID 0000-0001-8855-3029
Emory University · USBrigham and Women's Hospital · USCornell University · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLDR01DK056626 · NIDDK · YESHIVA UNIVERSITY · PI COHEN, DAVID E. · 2000 to 2024
$10.3M
Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLDR01DK103046 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVID E. COHEN, Susan J Hagen · 2015 to 2026
$7.6M
Regulation of Hepatic Lipid and Glucose Metabolism by Phosphatidylcholine TransfeR01DK048873 · NIDDK · YESHIVA UNIVERSITY · PI DAVID E. COHEN · 2003 to 2026
$5.8M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM008367 · NIGMS · EMORY UNIVERSITY · PI BOISE, LAWRENCE H., CORBETT, ANITA H. · 1990 to 2019
$5.6M
Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2R37DK048873 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI COHEN, DAVID E. · 2012 to 2021
$5.5M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETIONR29DK048873 · NIDDK · YESHIVA UNIVERSITY · PI COHEN, DAVID E · 1996 to 2000
$147k
Phosphatidylcholine transfer protein interacts with PPARd to modulate activityF31DK126435 · NIDDK · EMORY UNIVERSITY · PI DRUZAK, SAMUEL ADAM · 2020 to 2021
$92k
NCATS NIH HHS UL1 TR002378NIDDK NIH HHS F31 DK126435NIDDK NIH HHS R01 DK048873NIDDK NIH HHS R01 DK056626NIDDK NIH HHS R01 DK103046NIDDK NIH HHS R29 DK048873NIDDK NIH HHS R37 DK048873NIGMS NIH HHS T32 GM008367NIGMS NIH HHS T32 GM008602
6 · The paper itself

Abstract

Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding protein that transports phosphatidylcholine (PC) between cellular membranes. To better understand the protective metabolic effects associated with hepatic PC-TP, we generated a hepatocyte-specific PC-TP knockdown (L-Pctp

Indexed as

Fatty LiverPPAR deltaAnimalsDietLigandsLiverMaleMicePhosphatidylcholinesLigandsPhosphatidylcholinesPPAR delta

Identifiers

PMID37173315
PMCPMC10182070
OpenAlexW4376273342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.