Evidence map›Paper›PMID 37172964›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Brief pup separation during lactation confers resilience in behavioural deficits induced by chronic restraint stress in postpartum C57BL/6J dams.

Lin Zhou, Zuotian Wu, Dan Zhao, Gaohua Wang, Ling Xiao, Huiling Wang, Yumeng Xie, Limin Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Lin ZhouFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Zuotian WuFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Dan ZhaoFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Gaohua WangFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao) wgh6402@whu.edu.cn.
Ling XiaoFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Huiling WangFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Yumeng XieFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Limin SunFrom the Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China (Zhou, Wu, G. Wang, Xiao, H. Wang, Xie, Sun); the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Wu); the Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Zhao).
Union Hospital · CNHuazhong University of Science and Technology · CNRenmin Hospital of Wuhan University · CNUniversity of Copenhagen · DKWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe postpartum period is a complex time for females that affects health recovery. Stress during this period is one of the main risk factors for depression. Therefore, preventing stress-induced depression in the postpartum period is of great importance. Pup separation (PS) is a natural paradigm of postpartum care; however, the effect of different PS protocols during lactation on stress-induced depressive behaviours in dams is unknown.

methodsLactating C57BL/6J mice were subjected to no pup separation (NPS), brief PS (15 min/day, PS15) or long PS (180 min/day, PS180) from postpartum day 1 to postpartum day 21 and were then subjected to chronic restraint stress (CRS) for 21 days. Behavioural tests, specifically the open field test (OFT), elevated plus maze (EPM) test and tail suspension test (TST), were performed. The expression of mRNA and protein in the hippocampus and microbiota composition were also assessed.

resultsWe observed CRS-induced anxiety- and depression-like behaviours in NPS dams. In addition, in NPS dams, microglial activation and the levels of NOD-like receptor pyrin domain containing 3, caspase-1 and interleukin-1β were increased, whereas expression levels of collapsing response mediator protein 2 (CRMP2) and α-tubulin were decreased. However, immobility time in the TST was lower in PS15+CRS dams than in NPS+CRS dams, and time spent in the centre during the OFT and in the open arms during the EPM test was higher in PS15+CRS dams, indicating resilience. Expression of hippocampal biomarkers of neuroinflammation was inhibited and levels of CRMP2-mediated neuroplasticity were increased in PS15+CRS dams. Notably, we observed taxonomic changes in the cecal microbiota across different PS groups, as well as relationships between gut microbiota composition and some biomarkers of hippocampal neuroinflammation and neuroplasticity. LIMITATIONS: The sample size for gut microbiota analysis in this study was small.

conclusionCollectively, the results of this study confirm that brief PS confers stress resilience in CRS-induced behavioural deficits and reverses hippocampal neuroinflammation-neuroplasticity injury and gut microbiota imbalance.

Indexed as

LactationNeuroinflammatory DiseasesAnimalsDepressionFemaleHippocampusHumansMiceMice, Inbred C57BLPostpartum PeriodStress, Psychological

Identifiers

PMID37172964
PMCPMC10185353
OpenAlexW4376643524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.