Evidence map›Paper›PMID 37172104›Full record

ArticleScience immunology2023

Transcriptional programming of CD4

Quynh P Nguyen, Kennidy K Takehara, Tianda Z Deng, Shannon O'Shea, Maximilian Heeg, Kyla D Omilusik, J Justin Milner, Sara Quon, Matthew E Pipkin, Jinyong Choi and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  13. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Quynh P NguyenSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Kennidy K TakeharaSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-1990-155X
Tianda Z DengSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7795-350X
Shannon O'SheaSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Maximilian HeegSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9594-1377
Kyla D OmilusikSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3675-048X
J Justin MilnerSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0752-2130
Sara QuonSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3860-3491
Matthew E PipkinDepartment of Immunology and Microbiology, Scripps Research Institute, Jupiter, FL, USA.ORCID 0000-0002-9688-0190
Jinyong ChoiDepartment of Microbiology, College of Medicine, Catholic University of Korea, Seoul, South Korea.ORCID 0000-0003-2474-2837
Shane CrottyCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-6484-6262
Ananda W GoldrathSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5900-508X
University of California San Diego · USLa Jolla Institute for Immunology · USScripps Research Institute · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Transcription factor regulation of CD4 and CD8 T cell effector and memory differentiation and functionP01AI145815 · NIAID · UNIVERSITY OF FLORIDA · PI PIPKIN, MATTHEW EUGENE · 2020 to 2024
$11.0M
TF regulation of CD8 and CD4 T cell memory in both systemic and dermal infectionU19AI109976 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN · 2014 to 2018
$10.5M
Single-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8M
T cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1M
Regulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4M
Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
T cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0M
NCI NIH HHS P30 CA023100NIAID NIH HHS P01 AI132122NIAID NIH HHS P01 AI145815NIAID NIH HHS R01 AI067545NIAID NIH HHS R01 AI072117NIAID NIH HHS R37 AI067545NIAID NIH HHS U19 AI109976NIAMS NIH HHS T32 AR064194NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

After resolution of infection, T cells differentiate into long-lived memory cells that recirculate through secondary lymphoid organs or establish residence in tissues. In contrast to CD8

Indexed as

Immunologic MemoryVirus DiseasesCD4-Positive T-LymphocytesCell DifferentiationGene ExpressionHumans

Identifiers

PMID37172104
PMCPMC10350289
OpenAlexW4376254187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.